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Literature summary for 3.4.23.45 extracted from
- Characterization of the human beta-secretase 2 (BACE2) 5-flanking region: identification of a 268-bp region as the basal BACE2 promoter (2006), J. Mol. Neurosci., 29, 81-99.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DNA and amino acid sequence analysis, 5'-flanking region analysis, BACE2 mapping to chromosome 21q22.3, expression analysis, sequence comparison to BACE1 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-amyloid precursor protein APP + H2O | Homo sapiens | - |
beta-amyloid protein + beta-amyloid precursor protein pre-peptide | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| additional information | tissue-type specific expression, BACE2 expression is high in peripheral tissues and in brain regions including the postcentral gyrus and temporal lobes | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-amyloid precursor protein APP + H2O | - |
Homo sapiens | beta-amyloid protein + beta-amyloid precursor protein pre-peptide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BACE2 | - |
Homo sapiens |
| beta-secretase 2 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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