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Literature summary for 3.4.23.45 extracted from

  • Hussain, I.; Powell, D.J.; Howlett, D.R.; Chapman, G.A.; Gilmour, L.; Murdock, P.R.; Tew, D.G.; Meek, T.D.; Chapman, C.; Schneider, K.; Ratcliffe, S.J.; Tattersall, D.; Testa, T.T.; Southan, C.; Ryan, D.M.; Simmons, D.L.; Walsh, F.S.; Dingwall, C.; Christie, G.
    ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site (2000), Mol. Cell. Neurosci., 16, 609-619.
    View publication on PubMed
Search for more literature for 3.4.23.45

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-
Golgi apparatus
-
 Homo sapiens 5794
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 non-glycosylated, SDS-PAGE Homo sapiens
62000
-
 glycosylated, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid-beta precursor protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y5Z0 healthy and trisomy 21 patients
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
cerebral cortex
-
 Homo sapiens
-
medulla oblongata
-
 Homo sapiens
-
neuron
-
 Homo sapiens
-
spinal cord
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid-beta precursor protein + H2O
-
 Homo sapiens ?
-
 ?
amyloid-beta precursor protein + H2O results in increase of beta-secretase-derived soluble amyloid precursor protein and the corresponding carboxy-terminal fragment Homo sapiens ?
-
 ?
Swedish amyloid-beta pecursor protein + H2O
-
 Homo sapiens ?
-
 ?