BRENDA - Enzyme Database show
show all sequences of 3.4.23.4

Post X-ray crystallographic studies of chymosin specificity. The role of histidine-proline cluster of kappa-casein in catalytic reactions

Gustchina, E.A.; Majer, P.; Rumsh, L.D.; Ginodman, L.M.; Andreeva, N.S.; Adv. Exp. Med. Biol. 436, 179-184 (1998)

Data extracted from this reference:

Crystallization (Commentary)
Crystallization
Organism
-
Bos taurus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
kappa-casein + H2O
Bos taurus
cleaves a single bond in kappa-casein between phenylalanine 105 and methionine 106
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
His-Pro-His-Pro-His-Leu-Ser-Phe-Met-Ala-Ile-Pro-NH2 + H2O
part of the bovine kappa-casein sequence
36894
Bos taurus
His-Pro-His-Pro-His-Leu-Ser-Phe + Met-Ala-Ile-Pro + NH3
-
36894
Bos taurus
?
kappa-casein + H2O
cleaves a single bond in kappa-casein between phenylalanine 105 and methionine 106
36894
Bos taurus
?
-
-
-
-
Leu-Ser-Phe-Met-Ala-Ile-Pro-NH2 + H2O
part of the bovine kappa-casein sequence
36894
Bos taurus
Leu-Ser-Phe + Met-Ala-Ile-Pro + NH3
-
36894
Bos taurus
?
Crystallization (Commentary) (protein specific)
Crystallization
Organism
-
Bos taurus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
kappa-casein + H2O
Bos taurus
cleaves a single bond in kappa-casein between phenylalanine 105 and methionine 106
?
-
-
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
His-Pro-His-Pro-His-Leu-Ser-Phe-Met-Ala-Ile-Pro-NH2 + H2O
part of the bovine kappa-casein sequence
36894
Bos taurus
His-Pro-His-Pro-His-Leu-Ser-Phe + Met-Ala-Ile-Pro + NH3
-
36894
Bos taurus
?
kappa-casein + H2O
cleaves a single bond in kappa-casein between phenylalanine 105 and methionine 106
36894
Bos taurus
?
-
-
-
-
Leu-Ser-Phe-Met-Ala-Ile-Pro-NH2 + H2O
part of the bovine kappa-casein sequence
36894
Bos taurus
Leu-Ser-Phe + Met-Ala-Ile-Pro + NH3
-
36894
Bos taurus
?
Other publictions for EC 3.4.23.4
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
732234
Costabel
Influence of chymosin type and ...
Camelus dromedarius
J. Dairy Res.
82
375-384
2015
-
1
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
732235
Costabel
Influence of chymosin type and ...
Bos taurus
J. Dairy Res.
85
375-384
2015
-
1
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
732236
Jensen
The function of the milk-clott ...
Bos taurus, Camelus dromedarius
J. Dairy Sci.
98
2853-2860
2015
-
-
-
-
-
-
-
-
-
-
-
2
-
4
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
732866
Wang
Expression and characterizatio ...
Camelus dromedarius
Protein Expr. Purif.
111
75-81
2015
1
-
1
-
-
-
-
-
-
1
3
2
-
5
-
1
-
-
-
-
-
3
3
1
1
1
1
-
1
1
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
1
3
2
-
-
1
-
-
-
-
3
3
1
1
1
1
-
1
1
1
-
-
-
-
-
-
-
731169
Sun
Purification and characterizat ...
Rhizopus microsporus, Rhizopus microsporus F518
Appl. Biochem. Biotechnol.
174
174-185
2014
-
-
-
-
-
-
6
-
-
5
1
6
-
5
-
-
1
-
-
-
2
-
8
1
1
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
5
1
6
-
-
-
1
-
-
2
-
8
1
1
-
1
-
1
-
1
-
-
-
-
-
-
-
731924
Bijl
-
Chymosin-induced hydrolysis of ...
Bos taurus
Int. Dairy J.
39
215-221
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
732861
Noseda
Bioprocess and downstream opti ...
Bos taurus
Protein Expr. Purif.
104
85-91
2014
-
-
1
-
-
-
-
-
-
-
1
1
-
5
-
-
1
-
-
-
-
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
731064
Langholm Jensen
Camel and bovine chymosin: the ...
Bos taurus, Camelus dromedarius
Acta Crystallogr. Sect. D
69
901-913
2013
-
2
-
2
1
-
-
-
-
-
-
2
-
5
-
2
2
-
-
-
-
-
2
2
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
2
1
-
-
-
-
-
-
-
-
2
-
-
2
2
-
-
-
-
2
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
731839
Eskandari
-
Cloning, expression, purificat ...
Capra hircus
Food Biotechnol.
26
143-153
2012
-
1
1
-
-
1
-
-
-
-
1
1
-
1
-
-
1
-
1
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
1
1
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
731963
Moller
Comparison of the hydrolysis o ...
Bos taurus, Camelus dromedarius
J. Agric. Food Chem.
60
5454-5460
2012
-
2
-
-
-
-
-
-
-
-
-
2
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
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-
-
-
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2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
717696
Sorensen
Initial stage of cheese produc ...
Bos taurus, Camelus dromedarius
J. Agric. Food Chem.
59
5636-5647
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707523
Palmer
Bovine chymosin: a computation ...
Bos taurus
Biochemistry
49
2563-2573
2010
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
708213
Hidalgo
A study on bovine kappa-casein ...
Bos taurus
Colloids Surf. B Biointerfaces
76
556-563
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
708236
Kumar
Chymosin and other milk coagul ...
Bos taurus
Crit. Rev. Biotechnol.
30
243-258
2010
-
1
1
-
-
-
-
-
-
-
1
-
1
3
-
-
1
-
-
-
-
1
4
-
1
-
1
-
2
3
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
1
4
-
1
-
1
-
2
3
1
1
-
1
1
-
-
-
708952
Kageyama
Differences in the P1' substra ...
Bos taurus
J. Biochem.
147
167-174
2010
-
-
-
-
-
-
-
4
-
-
-
-
-
5
-
-
-
-
-
1
-
-
4
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
4
-
-
-
-
-
-
-
-
4
4
710493
Justesen
Recombinant chymosin used for ...
Bos taurus
Protein Sci.
18
1023-1032
2009
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698398
Vallejo
Cloning and expression of buff ...
Bubalus bubalis
J. Agric. Food Chem.
56
10606-10610
2008
-
-
1
-
-
-
-
1
-
-
1
-
-
7
-
-
-
-
-
1
-
-
2
1
1
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
2
1
1
1
-
-
1
-
-
-
-
-
-
-
-
-
686839
Kumar
-
Molecular cloning and expressi ...
Capra hircus
Food Biotechnol.
21
57-69
2007
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687229
Bansal
Aggregation of rennet-altered ...
Bos taurus
J. Agric. Food Chem.
55
3120-3126
2007
-
1
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687241
Renan
Limited enzymatic treatment of ...
Bos taurus
J. Agric. Food Chem.
55
6736-6745
2007
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687952
Reh
Partition features and renatur ...
Bos taurus
J. Chromatogr. B
860
98-105
2007
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
667435
Kappeler
Characterization of recombinan ...
Bos taurus, Camelus dromedarius
Biochem. Biophys. Res. Commun.
342
647-654
2006
-
1
1
-
-
-
-
4
-
-
2
-
-
5
-
-
1
-
-
3
-
-
8
-
4
2
1
4
2
4
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
4
-
-
2
-
-
-
-
1
-
3
-
-
8
-
4
2
1
4
2
4
1
-
-
-
-
-
-
-
667763
Starovoitova
A comparative study of functio ...
Bos taurus
Biochemistry (Moscow)
71
320-324
2006
-
-
1
-
-
-
1
12
-
-
-
-
-
4
-
-
1
-
-
2
-
-
7
-
-
-
1
11
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
12
-
-
-
-
-
-
-
1
-
2
-
-
7
-
-
-
1
11
-
-
1
-
-
-
-
-
-
-
668957
Huppertz
Inhibition of the proteolytic ...
Bos taurus
Int. dairy J.
16
691-696
2006
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
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1
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Buffalo (Bos buffali L.) chymo ...
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Properties of glycomacropeptid ...
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Beppu
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The cloning and expression of ...
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Raap
Peptide substrates for chymosi ...
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Moir
Molecular cloning and characte ...
Bos taurus
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1982
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Jensen
Isolation and partial characte ...
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Miyoshi
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1
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1
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1
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1
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1
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36881
Akaeda
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Studies on the rennin inhibito ...
Capra hircus, Equus caballus, Homo sapiens, Oryctolagus cuniculus, Ovis aries, Sus scrofa
Nippon Nogeikagaku Kaishi
45
449
1971
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6
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6
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6
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12
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6
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6
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12
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36882
Foltmann
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Prochymosin and chymosin (pror ...
Bos taurus
Methods Enzymol.
19
421-436
1970
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1
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4
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3
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1
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4
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1
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4
1
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1
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1
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1
3
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1
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4
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