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Literature summary for 3.4.23.38 extracted from

  • Mishra, V.; Rathore, I.; Arekar, A.; Sthanam, L.K.; Xiao, H.; Kiso, Y.; Sen, S.; Patankar, S.; Gustchina, A.; Hidaka, K.; Wlodawer, A.; Yada, R.Y.; Bhaumik, P.
    Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights (2018), FEBS J., 285, 3077-3096 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
KNI-10333 nanomolar inhibition activity Plasmodium falciparum
KNI-10743 nanomolar inhibition activity Plasmodium falciparum
pepstatin A
-
 Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
vacuole
-
 Plasmodium falciparum 5773
-

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
 isolate 3D7
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
EDANS-CO-CH2-CH2-CO-Ala-Leu-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-Dap-(DABCYL)-OH + H2O
-
 Plasmodium falciparum ?
-
 ?
Hemoglobin + H2O
-
 Plasmodium falciparum ?
-
 ?

Synonyms

Synonyms Comment Organism
PMI
-
 Plasmodium falciparum