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Literature summary for 3.4.23.38 extracted from

  • Tyas, L.; Gluzman, I.; Moon, R.P.; Rupp, K.; Westling, J.; Ridley, R.G.; Kay, J.; Goldberg, D.E.; Berry, C.
    Naturally-occurring and recombinant forms of the aspartic proteinases plasmepsins I and II from the human malaria parasite Plasmodium falciparum (1999), FEBS Lett., 454, 210-214.
    View publication on PubMed
Search for more literature for 3.4.23.38

Inhibitors

Inhibitors Comment Organism Structure
Iva-Val-Val-Sta-Ala-Sta
-
 Plasmodium falciparum
Ro40-4388
-
 Plasmodium falciparum
Ro40-5576
-
 Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
 Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys pH 4.4, 37°C, recombinant enzyme Plasmodium falciparum
0.005
-
 Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys pH 4.4, 37°C, recombinant enzyme Plasmodium falciparum
0.006
-
 Lys-Pro-Ile-Lys-Phe-Phe(NO2)-Arg-Leu pH 4.4, 37°C, naturally occuring enzyme Plasmodium falciparum
0.006
-
 Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys pH 4.4, 37°C, naturally occuring Plasmodium falciparum
0.008
-
 Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe pH 4.4, 37°C, naturally occuring enzyme Plasmodium falciparum
0.01
-
 Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe pH 4.4, 37°C, recombinant enzyme Plasmodium falciparum
0.01
-
 Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys pH 4.4, 37°C, recombinant enzyme Plasmodium falciparum
0.01
-
 Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys pH 4.4, 37°C, naturally occuring enzyme Plasmodium falciparum
0.015
-
 Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys pH 4.4, 37°C, naturally occuring enzyme Plasmodium falciparum
0.02
-
 Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys pH 4.4, 37°C, recombinant enzyme Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe + H2O
-
 Plasmodium falciparum Leu-Glu-Arg-Ile-Phe + Phe(NO2)-Ser-Phe
-
 ?
Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys + H2O
-
 Plasmodium falciparum Lys-Glu-Leu-Val-Phe + Phe(NO2)-Ala-Leu-Lys
-
 ?
Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys + H2O
-
 Plasmodium falciparum Lys-Glu-Phe-Asn-Phe + Phe(NO2)-Ala-Leu-Lys
-
 ?
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys + H2O
-
 Plasmodium falciparum Lys-Glu-Phe-Val-Phe + Phe(NO2)-Ala-Leu-Lys
-
 ?
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys + H2O
-
 Plasmodium falciparum Lys-Glu-Phe-Val-Phe + Phe(NO2)-Arg-Leu-Lys
-
 ?
Lys-Pro-Ile-Lys-Phe-Phe(NO2)-Arg-Leu + H2O
-
 Plasmodium falciparum Lys-Pro-Ile-Lys-Phe + Phe(NO2)-Arg-Leu
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.6
-
 Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys pH 4.4, 37°C, recombinant enzyme Plasmodium falciparum
2
-
 Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys pH 4.4, 37°C, recombinant enzyme Plasmodium falciparum
2.1
-
 Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe pH 4.4, 37°C, recombinant enzyme Plasmodium falciparum
3.5
-
 Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys pH 4.4, 37°C, recombinant enzyme Plasmodium falciparum
10
-
 Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys pH 4.4, 37°C, recombinant enzyme Plasmodium falciparum
10
-
 Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys pH 4.4, 37°C, naturally occuring enzyme Plasmodium falciparum
12
-
 Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys pH 4.4, 37°C, naturally occuring enzyme Plasmodium falciparum
16
-
 Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe pH 4.4, 37°C, naturally occuring enzyme Plasmodium falciparum
18
-
 Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys pH 4.4, 37°C, naturally occuring enzyme Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000005
-
 Iva-Val-Val-Sta-Ala-Sta pH 4.4, 37°C, naturally occuring enzyme Plasmodium falciparum
0.0000007
-
 Iva-Val-Val-Sta-Ala-Sta pH 4.4, 37°C, recombinant enzyme Plasmodium falciparum
0.000004
-
 Ro40-4388 pH 4.4, 37°C Plasmodium falciparum
0.000006
-
 Ro40-5576
-
 Plasmodium falciparum
0.000009
-
 Ro40-4388 naturally occuring enzyme Plasmodium falciparum