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Literature summary for 3.4.23.36 extracted from
- Lipoprotein processing is required for virulence of Mycobacterium tuberculosis (2004), Mol. Microbiol., 52, 1543-1552.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| ORF Rv1539, gene lspA, from strain H37Rv, DNA and amino acid sequence determination and analysis | Mycobacterium tuberculosis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | gene lspA disruption mutation by allelic replacement leads to attenuation of virulence and effects viability in murine macrophages, growth and phenotype, overview | Mycobacterium tuberculosis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mycobacterium tuberculosis | lipoprotein processing by LspA is required for virulence of the organism and acts as virulence determinant of tuberculosis | ? | - |
? |  |
| additional information | Mycobacterium tuberculosis H37Rv | lipoprotein processing by LspA is required for virulence of the organism and acts as virulence determinant of tuberculosis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
ORF Rv1539, gene lspA | - |
| Mycobacterium tuberculosis H37Rv | - |
ORF Rv1539, gene lspA | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | lipoprotein processing by LspA is required for virulence of the organism and acts as virulence determinant of tuberculosis | Mycobacterium tuberculosis | ? | - |
? | |
| additional information | lipoprotein processing by LspA is required for virulence of the organism and acts as virulence determinant of tuberculosis | Mycobacterium tuberculosis H37Rv | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 19000-27000, different enzyme expression forms, overview | Mycobacterium tuberculosis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lipoprotein signal peptidase | - |
Mycobacterium tuberculosis |
| lipoprotein-specific signal peptidase | - |
Mycobacterium tuberculosis |
| LspA | - |
Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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