Literature summary for 3.4.23.34 extracted from

Yasukochi, A.; Kawakubo, T.; Nakamura, S.; Yamamoto, K.
Cathepsin E enhances anticancer activity of doxorubicin on human prostate cancer cells showing resistance to TRAIL-mediated apoptosis (2010), Biol. Chem., 391, 947-958.

Search for more literature for 3.4.23.34

Application

Application	Comment	Organism
medicine	combination of cathepsin E and doxorubicin is sufficient to overcome resistance to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in chemoresistant prostate cancer PPC-1 cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
PPC-1 cell	-	Homo sapiens	-
prostate cancer cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	cathepsin E specifically induces growth arrest and apoptosis in a variety of human prostate cancer cell lines in vitro by catalyzing the proteolytic release of soluble tumor necrosis factor-related apoptosis-inducing ligand from tumor cell surface and prevents tumor growth and metastasis in vivo through multiple mechanisms, including induction of apoptosis angiogenesis inhibition and enhanced immune responses	Homo sapiens

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Release 2023.1 (January 2023)