Literature summary for 3.4.23.34 extracted from

Tsukuba, T.; Ikeda, S.; Okamoto, K.; Yasuda, Y.; Sakai, E.; Kadowaki, T.; Sakai, H.; Yamamoto, K.
Characterization of rat cathepsin E and mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells (2006), FEBS J., 273, 219-229.

Search for more literature for 3.4.23.34

Cloned(Commentary)

Cloned (Comment)	Organism
mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
D98A/D283A	mutant enzyme has no catalytic activity on either protein or synthetic substrates. In contrast with wild-type cathepsin E, the mutant enzyme is neither processed nor matured even after a 24-h chase period, but stably remains as a 46000 Da precursor	Rattus norvegicus
N324D	N-glycosylation-deficient mutant is neither processed into a mature form nor transported to the endosomal compartement, but is stable retained in the endoplasmic reticulum without degradation	Rattus norvegicus
N92Q	N-glycosylation-deficient mutant is neither processed into a mature form nor transported to the endosomal compartement, but is stable retained in the endoplasmic reticulum without degradation	Rattus norvegicus
N92Q/N374D	N-glycosylation-deficient mutant is neither processed into a mature form nor transported to the endosomal compartement, but is stable retained in the endoplasmic reticulum without degradation	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	N-glycosylation of cathepsin E plays an important role in its processing, maturation and trafficking to the appropriate destination in the cells, but is not necessarily essential for its correct folding	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining

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Release 2023.1 (January 2023)