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Literature summary for 3.4.23.34 extracted from

  • Robinson, P.S.; Lees, W.E.; Kay, J.; Cook, N.D.
    Kinetic parameters for the generation of endothelins-1,-2 and -3 by human cathepsin E (1992), Biochem. J., 284, 407-409.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.34

Inhibitors

Inhibitors Comment Organism Structure
(D)-His-Pro-Phe-His-Leu-PSI(CH2-NH)-Leu-Val-Tyr i.e. H-77, with reduced isostere as replacement of the-CO-NH- of the peptide bond Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.008
-
 big ET-2
-
 Homo sapiens
0.009
-
 big ET-1
-
 Homo sapiens
0.02
-
 big ET-3
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
big ET-1 + H2O
-
 Homo sapiens ?
-
 ?
Human endothelin precursor big ET-1 + H2O cleavage site: Trp-Val Homo sapiens Human endothelin precursor ET-1 + respective C-terminal fragment
-
 ?
Human endothelin precursor big ET-2 + H2O cleavage site: Trp-Val Homo sapiens Human endothelin precursor ET-2 + respective C-terminal fragment
-
 ?
Human endothelin precursor big ET-3 + H2O cleavage site: Trp-Ile Homo sapiens Huamn endothelin precursor ET-3 + respective C-terminal fragment
-
 ?
additional information no hydrolysis of synthetic peptides corresponding to residues His16-His27 and His16-Ser38 in the big ET-1 sequence Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.1
-
 big ET-2
-
 Homo sapiens
0.13
-
 big ET-1
-
 Homo sapiens
0.14
-
 big ET-3
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
3.3
-
 big ET-3 as substrate Homo sapiens
3.5 4.4 plateau, big ET-1 and 2 as substrates Homo sapiens