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Literature summary for 3.4.23.3 extracted from
- Progastriscin: Structure, function, and its role in tumor progression (2010), J. Mol. Cell Biol., 2, 118-127.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the tissue expression of progatricsin represents a powerful tool for the diagnosis of prostate cancer. The enzyme is also a biomarker for gastric carcinoma and plays a direct role in the development of breast tumor progression | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40000 | - |
x * 40000, calculated from amino acid sequence | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P20142 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gastric mucosa | - |
Homo sapiens | - |
| gastroduodenal mucosa | - |
Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
| seminal fluid | - |
Homo sapiens | - |
| seminal plasma | - |
Homo sapiens | - |
| seminal vesicle | - |
Homo sapiens | - |
| stomach | - |
Homo sapiens | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 40000, calculated from amino acid sequence | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| pepsinogen C | - |
Homo sapiens |
| PGC | - |
Homo sapiens |
| progastricsin | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the decrease of progastricsin expression indicates dedifferentiation or malignancy of cancer cells | down |
| Homo sapiens | progasticsin gene expression is up-regulated following gastrin, secretin, and forskolin stimulation of adenylate cyclase activity | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the major useful function of progastricsin (PGC) includes production of pro-antimicrobial substance in seminal plasma. The action of PGC in the stomach is to degrade dietary proteins. However, in seminal fluid, it activates defensins for local antimicrobial defense. On the other hand, intracellular proprotein activation by PGC in acidic organelle, such as in proSP-B proteolysis, is important on the processing in the secretory pathway of alveolar type-2 cells | Homo sapiens |
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