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Literature summary for 3.4.23.24 extracted from

  • Svoboda, E.; Schneider, A.E.; Sandor, N.; Lermann, U.; Staib, P.; Kremlitzka, M.; Bajtay, Z.; Barz, D.; Erdei, A.; Jozsi, M.
    Secreted aspartic protease 2 of Candida albicans inactivates factor H and the macrophage factor H-receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18) (2015), Immunol. Lett., 168, 13-21 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C3b + H2O Candida albicans
-
 ?
-
 ?
complement component C4b + H2O Candida albicans
-
 ?
-
 ?
complement component C5 + H2O Candida albicans
-
 ?
-
 ?
factor H + H2O Candida albicans the enzyme cleaves and inactivates factor H, diminishing its complement regulatory activity ?
-
 ?
macrophage factor H-receptor CR3 + H2O Candida albicans the enzyme cleaves and inactivates macrophage factor H-receptor CR3 ?
-
 ?
macrophage factor H-receptor CR4 + H2O Candida albicans the enzyme cleaves and inactivates macrophage factor H-receptor CR4 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3b + H2O
-
 Candida albicans ?
-
 ?
complement component C4b + H2O
-
 Candida albicans ?
-
 ?
complement component C5 + H2O
-
 Candida albicans ?
-
 ?
factor H + H2O the enzyme cleaves and inactivates factor H, diminishing its complement regulatory activity Candida albicans ?
-
 ?
macrophage factor H-receptor CR3 + H2O the enzyme cleaves and inactivates macrophage factor H-receptor CR3 Candida albicans ?
-
 ?
macrophage factor H-receptor CR4 + H2O the enzyme cleaves and inactivates macrophage factor H-receptor CR4 Candida albicans ?
-
 ?

Synonyms

Synonyms Comment Organism
SAP2
-
 Candida albicans
secreted aspartic protease 2
-
 Candida albicans