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Literature summary for 3.4.23.24 extracted from

  • Gropp, K.; Schild, L.; Schindler, S.; Hube, B.; Zipfel, P.F.; Skerka, C.
    The yeast Candida albicans evades human complement attack by secretion of aspartic proteases (2009), Mol. Immunol., 47, 465-475.
    View publication on PubMed
Search for more literature for 3.4.23.24

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Candida albicans

Inhibitors

Inhibitors Comment Organism Structure
Aprotinin
-
 Candida albicans
pepstatin A
-
 Candida albicans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38000
-
 isoform Sap3, SDS-PAGE Candida albicans
41000
-
 isoform Sap2, SDS-PAGE Candida albicans
42000
-
 isoform Sap1, SDS-PAGE Candida albicans

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O isoforms Sap1, Sap2, Sap3, and Sap9 cleave casein Candida albicans ?
-
 ?
complement components C3b + H2O substrate for isoforms Sap1, Sap2, Sap3, but not for Sap9 Candida albicans ?
-
 ?
complement components C4b + H2O substrate for isoforms Sap1, Sap2, Sap3, but not for Sap9 Candida albicans ?
-
 ?
complement components C5 + H2O substrate for isoforms Sap1, Sap2, Sap3, but not for Sap9 Candida albicans ?
-
 ?

Synonyms

Synonyms Comment Organism
SAP
-
 Candida albicans
SAP1 isoform Candida albicans
SAP2 isoform Candida albicans
SAP3 isoform Candida albicans
Sap9 isoform Candida albicans
secreted aspartic protease
-
 Candida albicans

General Information

General Information Comment Organism
physiological function isoforms Sap1, Sap2, and Sap3 degrade host complement components C3b, C4b and C5 and suppress host complement response. Saps inhibit C3b opsonization of Candida albicans and generation of the anaphylatoxin C5a in human plasma Candida albicans