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Literature summary for 3.4.23.22 extracted from

  • Hartman, A.M.; Mondal, M.; Radeva, N.; Klebe, G.; Hirsch, A.K.
    Structure-based optimization of inhibitors of the aspartic protease endothiapepsin (2015), Int. J. Mol. Sci., 16, 19184-19194 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.22

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-amino-3-(1H-indol-3-yl)-N'-[(E)-(2,4,6-trimethylphenyl)methylidene]propanehydrazide
-
 Cryphonectria parasitica
(2S)-2-amino-3-(1H-indol-3-yl)-N'-[(E)-(2-methylphenyl)methylidene]propanehydrazide
-
 Cryphonectria parasitica
(2S)-2-amino-3-(1H-indol-3-yl)-N'-[(E)-phenylmethylidene]propanehydrazide
-
 Cryphonectria parasitica
(2S)-2-amino-3-(1H-indol-3-yl)-N'-[(E)-[3-(trifluoromethyl)phenyl]methylidene]propanehydrazide
-
 Cryphonectria parasitica
(2S)-2-amino-3-(1H-indol-3-yl)-N'-[(E)-[4-(trifluoromethyl)phenyl]methylidene]propanehydrazide
-
 Cryphonectria parasitica
(2S)-2-amino-N'-[(E)-(2,6-dimethylphenyl)methylidene]-3-(1H-indol-3-yl)propanehydrazide
-
 Cryphonectria parasitica
(2S)-2-amino-N'-[(E)-(2-bromophenyl)methylidene]-3-(1H-indol-3-yl)propanehydrazide
-
 Cryphonectria parasitica
(2S)-2-amino-N'-[(E)-(2-fluorophenyl)methylidene]-3-(1H-indol-3-yl)propanehydrazide
-
 Cryphonectria parasitica
(2S)-2-amino-N'-[(E)-(2-hydroxy-3-methylphenyl)methylidene]-3-(1H-indol-3-yl)propanehydrazide
-
 Cryphonectria parasitica
(S)-2-amino-3-(1H-indol-3-yl)propanehydrazide
-
 Cryphonectria parasitica
2,6-dimethylbenzaldehyde
-
 Cryphonectria parasitica
2-Bromobenzaldehyde
-
 Cryphonectria parasitica
2-Fluorobenzaldehyde
-
 Cryphonectria parasitica
2-hydroxy-3-methylbenzaldehyde
-
 Cryphonectria parasitica
2-Methylbenzaldehyde
-
 Cryphonectria parasitica
3-(trifluoromethyl)benzaldehyde
-
 Cryphonectria parasitica
4-(trifluoromethyl)benzaldehyde
-
 Cryphonectria parasitica
benzaldehyde
-
 Cryphonectria parasitica

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0016
-
 Abz-Thr-Ile-Nle-4-nitro-Phe-Gln-Arg-NH2 at pH 4.6, temperature not specified in the publication Cryphonectria parasitica

Organism

Organism UniProt Comment Textmining
Cryphonectria parasitica P11838
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Cryphonectria parasitica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-Thr-Ile-Nle-4-nitro-Phe-Gln-Arg-NH2 + H2O
-
 Cryphonectria parasitica Abz-Thr-Ile-Nle + 4-nitro-Phe-Gln-Arg-NH2
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.007
-
 pH and temperature not specified in the publication Cryphonectria parasitica (2S)-2-amino-3-(1H-indol-3-yl)-N'-[(E)-[4-(trifluoromethyl)phenyl]methylidene]propanehydrazide
0.0128
-
 pH and temperature not specified in the publication Cryphonectria parasitica (2S)-2-amino-3-(1H-indol-3-yl)-N'-[(E)-(2,4,6-trimethylphenyl)methylidene]propanehydrazide
0.03
-
 pH and temperature not specified in the publication Cryphonectria parasitica (2S)-2-amino-N'-[(E)-(2,6-dimethylphenyl)methylidene]-3-(1H-indol-3-yl)propanehydrazide
0.036
-
 pH and temperature not specified in the publication Cryphonectria parasitica (2S)-2-amino-N'-[(E)-(2-hydroxy-3-methylphenyl)methylidene]-3-(1H-indol-3-yl)propanehydrazide
0.038
-
 pH and temperature not specified in the publication Cryphonectria parasitica (2S)-2-amino-N'-[(E)-(2-fluorophenyl)methylidene]-3-(1H-indol-3-yl)propanehydrazide
0.049
-
 pH and temperature not specified in the publication Cryphonectria parasitica (2S)-2-amino-3-(1H-indol-3-yl)-N'-[(E)-phenylmethylidene]propanehydrazide
0.0545
-
 pH and temperature not specified in the publication Cryphonectria parasitica (2S)-2-amino-N'-[(E)-(2-bromophenyl)methylidene]-3-(1H-indol-3-yl)propanehydrazide
0.059
-
 pH and temperature not specified in the publication Cryphonectria parasitica (2S)-2-amino-3-(1H-indol-3-yl)-N'-[(E)-(2-methylphenyl)methylidene]propanehydrazide
0.244
-
 pH and temperature not specified in the publication Cryphonectria parasitica (2S)-2-amino-3-(1H-indol-3-yl)-N'-[(E)-[3-(trifluoromethyl)phenyl]methylidene]propanehydrazide