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Literature summary for 3.4.23.20 extracted from

  • Fraser, M.E.; Meyer, J.H.; Bartlett, P.A.; James, M.N.
    Overcoming the unfavourable entropic contribution of ligand binding with a macrocyclic inhibitor bound to penicillopepsin (1998), Adv. Exp. Med. Biol., 436, 355-359.
    View publication on PubMed
Search for more literature for 3.4.23.20

Crystallization (Commentary)

Crystallization (Comment) Organism
cocrystallized with inhibitor 1-L, space group C2, cell dimensions a 0 97.88 A, b = 46.64 A, c = 66.59 A Penicillium sp.

Inhibitors

Inhibitors Comment Organism Structure
methyl (2S)-2-({hydroxy[({N-[(naphthalen-1-yl)acetyl]-L-valyl}amino)methyl]phosphoryl}oxy)-3-phenylpropanoate
-
 Penicillium sp.
methyl (2S)-2-({[(4S,7R)-2,5-dioxo-4-(propan-2-yl)-2,3,4,5,6,7-hexahydro-1H-8,10-etheno-3,6-benzodiazacycloundecin-7-yl](hydroxy)phosphoryl}oxy)-3-phenylpropanoate
-
 Penicillium sp.
methyl (2S)-2-({[(R)-[(N-formyl-L-valyl)amino](naphthalen-2-yl)methyl](hydroxy)phosphoryl}oxy)-3-phenylpropanoate
-
 Penicillium sp.

Organism

Organism UniProt Comment Textmining
Penicillium sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-Ala-Ala-Lys-(p-NO2)Phe-Ala-Ala-NH2 + H2O
-
 Penicillium sp. ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0008
-
 methyl (2S)-2-({[(4S,7R)-2,5-dioxo-4-(propan-2-yl)-2,3,4,5,6,7-hexahydro-1H-8,10-etheno-3,6-benzodiazacycloundecin-7-yl](hydroxy)phosphoryl}oxy)-3-phenylpropanoate
-
 Penicillium sp.
0.0076
-
 methyl (2S)-2-({[(R)-[(N-formyl-L-valyl)amino](naphthalen-2-yl)methyl](hydroxy)phosphoryl}oxy)-3-phenylpropanoate
-
 Penicillium sp.
0.11
-
 methyl (2S)-2-({hydroxy[({N-[(naphthalen-1-yl)acetyl]-L-valyl}amino)methyl]phosphoryl}oxy)-3-phenylpropanoate
-
 Penicillium sp.