Cloned (Comment) | Organism |
---|---|
a recombinant vaccinia virus vector is used to coexpress mouse prohormone convertase PC1 and PC2 in the constitutively secreting cell line BSC-40 and in the endocrine tissue-derived cell lines PC12 and AtT-20 | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Pro-opiomelanocortin + H2O | Mus musculus | physiological role of PC1 and PC2 as distinct proprotein convertases acting alone or together to produce a set of tissue-specific maturation products in the brain and in the peripheral tissues | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
a recombinant vaccinia virus vector is used to coexpress mouse prohormone convertase PC1 and PC2 in the constitutively secreting cell line BSC-40 and in the endocrine tissue-derived cell lines PC12 and AtT-20 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Pro-opiomelanocortin + H2O | - |
Mus musculus | Adrenocorticotropin + beta-lipotropin | PC2: beta-endorphin + an N-terminally extended corticotropin containing the joining peptide + either alpha-melanotropin or desacetyl-alpha-melanotropin | ? | |
Pro-opiomelanocortin + H2O | - |
Mus musculus | Adrenocorticotropin + beta-lipotropin | PC2 cleaves at the five pairs of basic residues, PC1 cleaves two of them preferentially | ? | |
Pro-opiomelanocortin + H2O | - |
Mus musculus | Adrenocorticotropin + beta-lipotropin | PC1: corticotropin + beta-lipotropin | ? | |
Pro-opiomelanocortin + H2O | physiological role of PC1 and PC2 as distinct proprotein convertases acting alone or together to produce a set of tissue-specific maturation products in the brain and in the peripheral tissues | Mus musculus | ? | - |
? |