Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gag polyprotein + H2O | Human immunodeficiency virus 1 | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gag polyprotein + H2O | - |
Human immunodeficiency virus 1 | ? | - |
? | |
additional information | the enzyme prefers to have large hydrophobic amino acids flanking the scissile bond. When P1' is proline, the P2 side chain interacts with a polar region in the S2 subsite of the enzyme, while the P2' amino acid interacts with a hydrophobic region of the S2' subsite. When P1' is not proline, the orientations of the P2 and P2' side chains with respect to the scissile bond are reversed. P2 residues interact with a hydrophobic face of the S2 subsite, while the P2' amino acid usually engages hydrophilic amino acids in the S2' subsite | Human immunodeficiency virus 1 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HIV-1 PR | - |
Human immunodeficiency virus 1 |
HIV-1 protease | - |
Human immunodeficiency virus 1 |