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Literature summary for 3.4.23.16 extracted from

  • Dumans, A.T.; Barreto, C.C.; Santos, A.F.; Arruda, M.; Sousa, T.M.; Machado, E.S.; Sabino, E.C.; Brindeiro, R.M.; Tanuri, A.; Duarte, A.J.; Soares, M.A.
    Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure (2009), Infect. Genet. Evol., 9, 62-70.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
A71T in untreated patients, mutations L10V, K20R, and M36I are more frequent in subtype F1, while L63P, A71T, and V77I are more prevalent in subtype B Human immunodeficiency virus 1
D30N in treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1 Human immunodeficiency virus 1
G73S in treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1 Human immunodeficiency virus 1
I84V in treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1 Human immunodeficiency virus 1
K20M in treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1 Human immunodeficiency virus 1
K20R in untreated patients, mutations L10V, K20R, and M36I are more frequent in subtype F1, while L63P, A71T, and V77I are more prevalent in subtype B Human immunodeficiency virus 1
K20T in treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1 Human immunodeficiency virus 1
L10V in untreated patients, mutations L10V, K20R, and M36I are more frequent in subtype F1, while L63P, A71T, and V77I are more prevalent in subtype B Human immunodeficiency virus 1
L63P in untreated patients, mutations L10V, K20R, and M36I are more frequent in subtype F1, while L63P, A71T, and V77I are more prevalent in subtype B Human immunodeficiency virus 1
L90M in treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1 Human immunodeficiency virus 1
M36I in untreated patients, mutations L10V, K20R, and M36I are more frequent in subtype F1, while L63P, A71T, and V77I are more prevalent in subtype B Human immunodeficiency virus 1
additional information comparison of the differences between subtypes B and F1 in the acquisition of major and minor protease inhibitor-associated resistance mutations and other polymorphisms in the protease gene. In untreated patients, mutations L10V, K20R, and M36I are more frequent in subtype F1, while L63P, A71T, and V77I are more prevalent in subtype B. In treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1. A higher proportion of subtype F1 than of subtype B strains containing other polymorphisms is observed. V82L mutation is present with increased frequency in isolates from children compared to isolates from adults infected with both subtypes Human immunodeficiency virus 1
N88S in treated patients, K20M, D30N, G73S, I84V, and L90M, are more prevalent in subtype B, and K20T and N88S are more prevalent in subtype F1 Human immunodeficiency virus 1
V77I in untreated patients, mutations L10V, K20R, and M36I are more frequent in subtype F1, while L63P, A71T, and V77I are more prevalent in subtype B Human immunodeficiency virus 1
V82L mutation is present with increased frequency in isolates from children compared to isolates from adults infected with both subtypes B and F1 Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
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subtypes B and F1
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