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Literature summary for 3.4.23.16 extracted from

  • Clemente, J.C.; Robbins, A.; Grana, P.; Paleo, M.R.; Correa, J.F.; Villaverde, M.C.; Sardina, F.J.; Govindasamy, L.; Agbandje-McKenna, M.; McKenna, R.; Dunn, B.M.; Sussman, F.
    Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation (2008), J. Med. Chem., 51, 852-860.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation Human immunodeficiency virus 1

Inhibitors

Inhibitors Comment Organism Structure
(2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-1,6-dicyclohexylhexane-3,4-diol compound has an improved response to V82A mutant enzyme Human immunodeficiency virus 1
(2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-1,6-diphenylhexane-3,4-diol
-
 Human immunodeficiency virus 1
(2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-6-cyclohexyl-1-phenylhexane-3,4-diol compound has an improved response to V82A mutant enzyme Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000013
-
 (2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-1,6-diphenylhexane-3,4-diol native enzyme Human immunodeficiency virus 1
0.0000023
-
 (2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-6-cyclohexyl-1-phenylhexane-3,4-diol native enzyme Human immunodeficiency virus 1
0.000006
-
 (2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-1,6-dicyclohexylhexane-3,4-diol native enzyme Human immunodeficiency virus 1
0.000009
-
 (2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-1,6-diphenylhexane-3,4-diol mutant enzyme V82A Human immunodeficiency virus 1
0.000012
-
 (2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-1,6-dicyclohexylhexane-3,4-diol mutant enzyme V82A Human immunodeficiency virus 1
0.000014
-
 (2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-6-cyclohexyl-1-phenylhexane-3,4-diol mutant enzyme V82A Human immunodeficiency virus 1