Literature summary for 3.4.23.16 extracted from

Porter, D.J.; Hanlon, M.H.; Furfine, E.S.
HIV-1 protease: characterization of a catalytically competent enzyme-substrate intermediate (2002), Biochemistry, 41, 1302-1307.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0021	-	2-aminobenzoyl-TI-Nle-Phe(NO2)-QR-NH2	pH 6.0, 25°C	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-aminobenzoyl-TI-Nle-Phe(NO2)-QR-NH2 + H2O	the enzyme reacts with the substrate to give an initial enzyme-substrate complex that isomerizes to a kinetically competent intermediate EX	Human immunodeficiency virus 1	2-aminobenzoyl-Thr-Ile-Nle + Phe(NO2)-Gln-Arg-NH2	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
7.4	-	2-aminobenzoyl-TI-Nle-Phe(NO2)-QR-NH2	pH 6.0, 25°C	Human immunodeficiency virus 1

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Release 2023.1 (January 2023)