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Literature summary for 3.4.23.16 extracted from
- Defining HIV-1 protease substrate selectivity (2002), Curr. Drug Targets Infect. Disord., 2, 37-50.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | drugs against protease and reverse transcriptase form the basis for Highly Active Anti-Retroviral Theraphy that has been successful in improving survival rates and quality of life for HIV infected individuals | Human immunodeficiency virus 1 |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D30N | drug resistance with nelfinavir | Human immunodeficiency virus 1 |
| G48V | the kcat/Km ratio for the substrate KARVLAEAMS is 55% of that for the autoproteolysis resistant variant Q7K/L33I/L63I/C67A/C95A | Human immunodeficiency virus 1 |
| G48V | drug resistance with saquinavir | Human immunodeficiency virus 1 |
| L90M | drug resistance with indinavir and saquinavir | Human immunodeficiency virus 1 |
| M46I | drug resistance with indinavir | Human immunodeficiency virus 1 |
| N88D | drug resistance with nelfinavir | Human immunodeficiency virus 1 |
| V82A | drug resistance with ritonavir, saquinavir and indinavir | Human immunodeficiency virus 1 |
| V82F | drug resistance with ritonavir and indinavir | Human immunodeficiency virus 1 |
| V82S | drug resistance with ritonavir | Human immunodeficiency virus 1 |
| V82T | drug resistance with ritonavir and indinavir | Human immunodeficiency virus 1 |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| NaCl | the protease works more efficiently at high salt concentrations, 2 M NaCl, than at lower salt concentrations | Human immunodeficiency virus 1 |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human immunodeficiency virus 1 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ARVLAEAM + H2O | - |
Human immunodeficiency virus 1 | ARVL + AEAM | - |
? | |
| ATHDVY-Phe(NO2)-VRKA + H2O | - |
Human immunodeficiency virus 1 | ATHDVY + Phe(NO2)-VRKA | - |
? | |
| ATHNVY-Phe(NO2)-VRKA + H2O | - |
Human immunodeficiency virus 1 | ATHNVY + Phe(NO2)-VRKA | - |
? | |
| ATHQVY-Phe(NO2)-VRKA + H2O | - |
Human immunodeficiency virus 1 | ATHQVY + Phe(NO2)-VRKA | - |
? | |
| ATHRVY-Phe(NO2)-VRKA + H2O | - |
Human immunodeficiency virus 1 | ATHRVY + Phe(NO2)-VRKA | - |
? | |
| ATHVVY-Phe(NO2)-VRKA + H2O | - |
Human immunodeficiency virus 1 | ATHVVY + Phe(NO2)-VRKA | - |
? | |
| ATHYVY-Phe(NO2)-VRKA + H2O | - |
Human immunodeficiency virus 1 | ATHYVY + Phe(NO2)-VRKA | - |
? | |
| KAQNYPIA-Nle + H2O | - |
Human immunodeficiency virus 1 | KAQNY + PIA-Nle | - |
? | |
| KAQNYPIV-Nle + H2O | - |
Human immunodeficiency virus 1 | KAQNY + PIV-Nle | - |
? | |
| KARA-Nle-Phe(NO2)-EA-Nle + H2O | - |
Human immunodeficiency virus 1 | KARA-Nle + Phe(NO2)-EA-Nle | - |
? | |
| KARI-Nle-Phe(NO2)-EA-Nle + H2O | - |
Human immunodeficiency virus 1 | KARI-Nle + Phe(NO2)-EA-Nle | - |
? | |
| KARL-Nle-Phe(NO2)-EA-Nle + H2O | - |
Human immunodeficiency virus 1 | KARL-Nle + Phe(NO2)-EA-Nle | - |
? | |
| KARN-Nle-Phe(NO2)-EA-Nle + H2O | - |
Human immunodeficiency virus 1 | KARN-Nle + Phe(NO2)-EA-Nle | - |
? | |
| KARNYPA-Nle + H2O | - |
Human immunodeficiency virus 1 | KARNY + PA-Nle | - |
? | |
| KARNYPE-Nle + H2O | - |
Human immunodeficiency virus 1 | KARNY + PE-Nle | - |
? | |
| KARNYPI-Nle + H2O | - |
Human immunodeficiency virus 1 | KARNY + PI-Nle | - |
? | |
| KARNYPN-Nle + H2O | - |
Human immunodeficiency virus 1 | KARNY + PN-Nle | - |
? | |
| KARNYPQ-Nle + H2O | - |
Human immunodeficiency virus 1 | KARNY + PQ-Nle | - |
? | |
| KARNYPV-Nle + H2O | - |
Human immunodeficiency virus 1 | KARNY + PV-Nle | - |
? | |
| KARV-Nle-Phe(NO2)-AA-Nle + H2O | - |
Human immunodeficiency virus 1 | KARV-Nle + Phe(NO2)-AA-Nle | - |
? | |
| KARV-Nle-Phe(NO2)-EA-Nle + H2O | - |
Human immunodeficiency virus 1 | KARV-Nle + Phe(NO2)-EA-Nle | - |
? | |
| KARV-Nle-Phe(NO2)-IA-Nle + H2O | - |
Human immunodeficiency virus 1 | KARV-Nle + Phe(NO2)-IA-Nle | - |
? | |
| KARV-Nle-Phe(NO2)-NA-Nle + H2O | - |
Human immunodeficiency virus 1 | KARV-Nle + Phe(NO2)-NA-Nle | - |
? | |
| KARV-Nle-Phe(NO2)-QA-Nle + H2O | - |
Human immunodeficiency virus 1 | KARV-Nle + Phe(NO2)-QA-Nle | - |
? | |
| KARV-Nle-Phe(NO2)-TA-Nle + H2O | - |
Human immunodeficiency virus 1 | KARV-Nle + Phe(NO2)-TA-Nle | - |
? | |
| KARV-Nle-Phe(NO2)-VA-Nle + H2O | - |
Human immunodeficiency virus 1 | KARV-Nle + Phe(NO2)-VA-Nle | - |
? | |
| KARVMPhe(NO2)-EA-Nle + H2O | - |
Human immunodeficiency virus 1 | KARVM + Phe(NO2)-EA-Nle | - |
? | |
| KARVYPhe(NO2)-EA-Nle + H2O | - |
Human immunodeficiency virus 1 | KARVY + Phe(NO2)-EA-Nle | - |
? | |
| PFAVSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PFAVS + LAMTMRR | - |
? | |
| PGAVSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PGAVS + LAMTMRR | - |
? | |
| PHAVSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PHAVS + LAMTMRR | - |
? | |
| PLAVSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PLAVS + LAMTMRR | - |
? | |
| PNAVSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PNAVS + LAMTMRR | - |
? | |
| PPAGSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAGS + LAMTMRR | - |
? | |
| PPAHSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAHS + LAMTMRR | - |
? | |
| PPALSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPALS + LAMTMRR | - |
? | |
| PPASSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPASS + LAMTMRR | - |
? | |
| PPAVALAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVA + LAMTMRR | - |
? | |
| PPAVELAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVE + LAMTMRR | - |
? | |
| PPAVGLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVG + LAMTMRR | - |
? | |
| PPAVHLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVH + LAMTMRR | - |
? | |
| PPAVLLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVL + LAMTMRR | - |
? | |
| PPAVRLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVR + LAMTMRR | - |
? | |
| PPAVSEAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVS + EAMTMRR | - |
? | |
| PPAVSFAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVS + FAMTMRR | - |
? | |
| PPAVSGAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVS + GAMTMRR | - |
? | |
| PPAVSLALTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVS + LALTMRR | - |
? | |
| PPAVSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVS + LAMTMRR | - |
? | |
| PPAVSLANTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVS + LANTMRR | - |
? | |
| PPAVSLAYTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVS + LAYTMRR | - |
? | |
| PPAVSLGMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVS + LGMTMRR | - |
? | |
| PPAVSLHMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVS + LHMTMRR | - |
? | |
| PPAVSLLMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVS + LLMTMRR | - |
? | |
| PPAVSLSMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVS + LSMTMRR | - |
? | |
| PPAVSQAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVS + QAMTMRR | - |
? | |
| PPAVSRAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVS + RAMTMRR | - |
? | |
| PPAVWLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAVW + LAMTMRR | - |
? | |
| PPAWSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPAWS + LAMTMRR | - |
? | |
| PPDVSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPDVS + LAMTMRR | - |
? | |
| PPFVSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPFVS + LAMTMRR | - |
? | |
| PPGVSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPGVS + LAMTMRR | - |
? | |
| PPHVSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPHVS + LAMTMRR | - |
? | |
| PPNVSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPNVS + LAMTMRR | - |
? | |
| PPPVSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPPVS + LAMTMRR | - |
? | |
| PPRVSLAMTMRR + H2O | - |
Human immunodeficiency virus 1 | PPRVS + LAMTMRR | - |
? | |
| SANYPIV + H2O | - |
Human immunodeficiency virus 1 | SANY + PIV | - |
? | |
| SCNYPIV + H2O | - |
Human immunodeficiency virus 1 | SCNY + PIV | - |
? | |
| SDNYPIV + H2O | - |
Human immunodeficiency virus 1 | SDNY + PIV | - |
? | |
| SENYPIV + H2O | - |
Human immunodeficiency virus 1 | SENY + PIV | - |
? | |
| SFNYPIV + H2O | - |
Human immunodeficiency virus 1 | SFNY + PIV | - |
? | |
| SGNYPIV + H2O | - |
Human immunodeficiency virus 1 | SGNY + PIV | - |
? | |
| SHNYPIV + H2O | - |
Human immunodeficiency virus 1 | SHNY + PIV | - |
? | |
| SINYPIV + H2O | - |
Human immunodeficiency virus 1 | SINY + PIV | - |
? | |
| SKNYPIV + H2O | - |
Human immunodeficiency virus 1 | SKNY + PIV | - |
? | |
| SLNYPIV + H2O | - |
Human immunodeficiency virus 1 | SLNY + PIV | - |
? | |
| SMNYPIV + H2O | - |
Human immunodeficiency virus 1 | SMNY + PIV | - |
? | |
| SNNYPIV + H2O | - |
Human immunodeficiency virus 1 | SNNY + PIV | - |
? | |
| SQAYPIV + H2O | - |
Human immunodeficiency virus 1 | SQAY + PIV | - |
? | |
| SQCYPIV + H2O | - |
Human immunodeficiency virus 1 | SQCY + PIV | - |
? | |
| SQDYPIV + H2O | - |
Human immunodeficiency virus 1 | SQDY + PIV | - |
? | |
| SQEYPIV + H2O | - |
Human immunodeficiency virus 1 | SQEY + PIV | - |
? | |
| SQNFPIV + H2O | - |
Human immunodeficiency virus 1 | SQNF + PIV | - |
? | |
| SQNLPIV + H2O | - |
Human immunodeficiency virus 1 | SQNL + PIV | - |
? | |
| SQNMPIV + H2O | - |
Human immunodeficiency virus 1 | SQNM + PIV | - |
? | |
| SQNWPIV + H2O | - |
Human immunodeficiency virus 1 | SQNW + PIV | - |
? | |
| SQNYAIV + H2O | - |
Human immunodeficiency virus 1 | SQNY + AIV | - |
? | |
| SQNYFIV + H2O | - |
Human immunodeficiency virus 1 | SQNY + FIV | - |
? | |
| SQNYIIV + H2O | - |
Human immunodeficiency virus 1 | SQNY + IIV | - |
? | |
| SQNYLIV + H2O | - |
Human immunodeficiency virus 1 | SQNY + LIV | - |
? | |
| SQNYMIV + H2O | - |
Human immunodeficiency virus 1 | SQNY + MIV | - |
? | |
| SQNYPAV + H2O | - |
Human immunodeficiency virus 1 | SQNY + PAV | - |
? | |
| SQNYPIV + H2O | - |
Human immunodeficiency virus 1 | SQNY + PIV | - |
? | |
| SQNYPLV + H2O | - |
Human immunodeficiency virus 1 | SQNY + PLV | - |
? | |
| SQNYVIV + H2O | - |
Human immunodeficiency virus 1 | SQNY + VIV | - |
? | |
| SQNYWIV + H2O | - |
Human immunodeficiency virus 1 | SQNY + WIV | - |
? | |
| SQNYYIV + H2O | - |
Human immunodeficiency virus 1 | SQNY + YIV | - |
? | |
| SQVYPIV + H2O | - |
Human immunodeficiency virus 1 | SQVY + PIV | - |
? | |
| SRNYPIV + H2O | - |
Human immunodeficiency virus 1 | SRNY + PIV | - |
? | |
| SSNYPIV + H2O | - |
Human immunodeficiency virus 1 | SSNY + PIV | - |
? | |
| STNYPIV + H2O | - |
Human immunodeficiency virus 1 | STNY + PIV | - |
? | |
| SWNYPIV + H2O | - |
Human immunodeficiency virus 1 | SWNY + PIV | - |
? | |
| SYNYPIV + H2O | - |
Human immunodeficiency virus 1 | SYNY + PIV | - |
? | |
| VAQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | VAQNY + PIVQ | - |
? | |
| VDQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | VDQNY + PIVQ | - |
? | |
| VFQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | VFQNY + PIVQ | - |
? | |
| VGQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | VGQNY + PIVQ | - |
? | |
| VIQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | VIQNY + PIVQ | - |
? | |
| VKQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | VKQNY + PIVQ | - |
? | |
| VLQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | VLQNY + PIVQ | - |
? | |
| VMQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | VMQNY + PIVQ | - |
? | |
| VNQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | VNQNY + PIVQ | - |
? | |
| VPQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | VPQNY + PIVQ | - |
? | |
| VRQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | VRQNY + PIVQ | - |
? | |
| VSQNYPIDQ + H2O | - |
Human immunodeficiency virus 1 | VSQNY + PIDQ | - |
? | |
| VSQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | VSQNY + PIVQ | - |
? | |
| VTQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | VTQNY + PIVQ | - |
? | |
| VVQNYPIVQ + H2O | - |
Human immunodeficiency virus 1 | VVQNY + PIVQ | - |
? | |
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