Application | Comment | Organism |
---|---|---|
medicine | the enzyme is an attractive target for antiviral drugs of HIV-1 | Human immunodeficiency virus 1 |
Cloned (Comment) | Organism |
---|---|
the enzyme is cloned in pMAL-cRI and expressed as a MBP-pol fusion protein in Escherichia coli XL1-blue | Human immunodeficiency virus 1 |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0098 | - |
His-Lys-Ala-Arg-Val-Leu-(4-nitro)Phe-Glu-Ala-Nle-Ser-amide | - |
Human immunodeficiency virus 1 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Human immunodeficiency virus 1 | the enzyme is essential for the replication of the virus | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Human immunodeficiency virus 1 |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
His-Lys-Ala-Arg-Val-Leu-(4-nitro)Phe-Glu-Ala-Nle-Ser-amide + H2O | - |
Human immunodeficiency virus 1 | His-Lys-Ala-Arg-Val-Leu + (4-nitro)Phe-Glu-Ala-Nle-Ser-amide | - |
? | |
additional information | the enzyme exhibits autoprocessing | Human immunodeficiency virus 1 | ? | - |
? | |
additional information | the enzyme is essential for the replication of the virus | Human immunodeficiency virus 1 | ? | - |
? |