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Literature summary for 3.4.23.16 extracted from

  • Ringe, D.
    X-ray structures of retroviral proteases and their inhibitor-bound complexes (1994), Methods Enzymol., 241, 157-177.
    View publication on PubMed
Search for more literature for 3.4.23.16

Inhibitors

Inhibitors Comment Organism Structure
2-(2-{5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-2,6-diphenyl-hexanoylamino}-3-methyl-butyrylamino)-3-methyl-butyric acid methyl ester
-
 Human immunodeficiency virus 1
2-(2-{5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-2-methyl-6-phenyl-hexanoylamino}-3-methyl-butyrylamino)-3-methyl-butyric acid methyl ester
-
 Human immunodeficiency virus 1
2-(2-{5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-6-phenyl-2-propyl-hexanoylamino}-3-methyl-butyrylamino)-3-methyl-butyric acid methyl ester
-
 Human immunodeficiency virus 1
2-(2-{5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-6-phenyl-hexanoylamino}-3-methyl-butyrylamino)-3-methyl-butyric acid methyl ester
-
 Human immunodeficiency virus 1
A74704
-
 Human immunodeficiency virus 1
Ac-His-Gly-Trp-Ile-PSI[N-CH(CH2(CH3)2)-CH(OH)-CH2-CH2-C(O)]-Glu-His-Gly-Asp-NH2
-
 Human immunodeficiency virus 1
JG365
-
 Human immunodeficiency virus 1
L-700,417 IC50: 0.67 mM Human immunodeficiency virus 1
MVT-101
-
 Human immunodeficiency virus 1
SB204,144
-
 Human immunodeficiency virus 1
SKF 107457
-
 Human immunodeficiency virus 1
SKF 108361
-
 Human immunodeficiency virus 1
U-75875
-
 Human immunodeficiency virus 1
U-85548E
-
 Human immunodeficiency virus 1
UCSF8
-
 Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000024
-
 JG-365
-
 Human immunodeficiency virus 1
0.0000006
-
 2-[2-[5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-2,6-diphenyl-hexanoylamino]-3-methyl-butyrylamino]-3-methyl-butyric acid methyl ester
-
 Human immunodeficiency virus 1
0.0000012
-
 2-[2-[5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-6-phenyl-2-propyl-hexanoylamino]-3-methyl-butyrylamino]-3-methyl-butyric acid methyl ester
-
 Human immunodeficiency virus 1
0.0000028
-
 SB-204,144
-
 Human immunodeficiency virus 1
0.000003
-
 2-[2-[5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-2-methyl-6-phenyl-hexanoylamino]-3-methyl-butyrylamino]-3-methyl-butyric acid methyl ester
-
 Human immunodeficiency virus 1
0.000004
-
 2-[2-[5-[2-(2-amino-propionylamino)-propionylamino]-4-hydroxy-6-phenyl-hexanoylamino]-3-methyl-butyrylamino]-3-methyl-butyric acid methyl ester
-
 Human immunodeficiency virus 1
0.0000045
-
 A-74704
-
 Human immunodeficiency virus 1
0.0000052
-
 Ac-His-Gly-Trp-Ile-PSI[N-CH(CH2(CH3)2)-CH(OH)-CH2-CH2-C(O)]-Glu-His-Gly-Asp-NH2
-
 Human immunodeficiency virus 1
0.000018
-
 SKF 107457
-
 Human immunodeficiency virus 1
0.000178
-
 MVT-101
-
 Human immunodeficiency virus 1
0.015
-
 UCSF8
-
 Human immunodeficiency virus 1

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.67
-
 IC50: 0.67 mM Human immunodeficiency virus 1 L-700,417