Literature summary for 3.4.23.16 extracted from

Miller, M.; Schneider, J.; Sathyanarayana, B.K.; Toth, M.V.; Marshall, G.R.; Clawson, L.; Selk, L.; Kent, S.B.H.; Wlodawer, A.
Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution (1989), Science, 246, 1149-1152.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
crystallization of a complex between the chemically synthesized HIV-1 protease and the peptide inhibitor N-acetyl-Thr-Ile-Nle-PSI[CH2-NH]-Nle-Gln-Arg-amide	Human immunodeficiency virus 1

Inhibitors

Inhibitors	Comment	Organism	Structure
MVT-101	-	Human immunodeficiency virus 1

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.4	-	Ac-TIMMQR-NH2	-	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	the enzyme is chemically synthesized	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ac-TIMMQR-NH2 + H2O	-	Human immunodeficiency virus 1	Ac-TIM + MQR-NH2	-	?

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Release 2023.1 (January 2023)