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Literature summary for 3.4.23.15 extracted from
- The increase in renin during renin inhibition: does it result in harmful effects by the (pro)renin receptor? (2010), Hypertens. Res., 33, 4-10.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aliskiren | renin inhibition is more than 99% at 5 h after the 300 and 600 mg aliskiren doses | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensinogen + H2O | Homo sapiens | - |
angiotensin I + angiotensinogen propeptide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensinogen + H2O | - |
Homo sapiens | angiotensin I + angiotensinogen propeptide | - |
? | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000006 | - |
pH and temperature not specified in the publication | Homo sapiens | aliskiren | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | renin inhibitors like aliskiren increase the plasma concentration of renin because they attenuate the negative feedback effect of angiotensin II on renin release | up |
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Release 2023.1 (January 2023)
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