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Literature summary for 3.4.23.15 extracted from
- Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure (2009), Circulation, 2, 532-540.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensinogen + H2O | Ovis aries | - |
angiotensin I + angiotensinogen propeptide | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ovis aries | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Ovis aries | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensinogen + H2O | - |
Ovis aries | angiotensin I + angiotensinogen propeptide | - |
? | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Ovis aries | treatment with 0.05 mg urocortin 2 or 0.05 mg urocortin 2 plus 20 mg furosemide markedly reduces plasma renin activity | down |
| Ovis aries | 20 mg furosemide induces activation of renin | up |
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Release 2023.1 (January 2023)
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