Literature summary for 3.4.23.15 extracted from

Schmieder, R.E.; Philipp, T.; Guerediaga, J.; Gorostidi, M.; Smith, B.; Weissbach, N.; Maboudian, M.; Botha, J.; van Ingen, H.
Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: a 12-month randomized, double-blind comparator trial with hydrochlorothiazide (2009), Circulation, 119, 417-425.

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Application

Application	Comment	Organism
medicine	direct renin inhibition with aliskiren represents an effective option for the long-term treatment of essential hypertension	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
aliskiren	oral direct renin inhibitor	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
angiotensinogen + H2O	Homo sapiens	-	angiotensin I + angiotensinogen propeptide	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
angiotensinogen + H2O	-	Homo sapiens	angiotensin I + angiotensinogen propeptide	-	?

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Release 2023.1 (January 2023)