Literature summary for 3.4.23.15 extracted from

  • Takahashi, S.; Hori, K.; Hokari, M.; Gotoh, T.; Sugiyama, T.
    Inhibition of human renin activity by saponins (2010), Biomed. Res., 31, 155-159.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2'-O-beta-D-glucopyranosyl momordin Ic
-
Homo sapiens
2'-O-beta-D-glucopyranosyl momordin IIc
-
Homo sapiens
chikusetsusaponin IV
-
Homo sapiens
glycyrrhizin
-
Homo sapiens
momordin Ic
-
Homo sapiens
momordin IIc
-
Homo sapiens
monoglucuronyl glycyrrhetic acid
-
Homo sapiens
additional information renin is not inhibited by soyasapogenol B glycyrrhetic acid, saikosaponin b2, saikosaponin c and ginsenoside Rb1 Homo sapiens
soyasaponin I
-
Homo sapiens
soyasaponin II
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensinogen + H2O Homo sapiens
-
angiotensin I + angiotensinogen propeptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensinogen + H2O
-
Homo sapiens angiotensin I + angiotensinogen propeptide
-
?
N-methylanthranyl-Ile-His-Pro-Phe-His-Leu-Val-Ile-Thr-His-Lys-2,4-dinitrophenyl-D-Arg-D-Arg-NH2 + H2O
-
Homo sapiens N-methylanthranyl-Ile-His-Pro-Phe-His-Leu + Val-Ile-Thr-His-Lys-2,4-dinitrophenyl-D-Arg-D-Arg-NH2
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0422
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C Homo sapiens monoglucuronyl glycyrrhetic acid
0.0303
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C Homo sapiens soyasaponin II
0.0194
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C Homo sapiens 2'-O-beta-D-glucopyranosyl momordin Ic
0.0384
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C Homo sapiens 2'-O-beta-D-glucopyranosyl momordin IIc
0.0571
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C Homo sapiens glycyrrhizin
0.0774
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C Homo sapiens chikusetsusaponin IV
0.0259
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C Homo sapiens momordin Ic
0.0468
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C Homo sapiens momordin IIc
0.0336
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C Homo sapiens soyasaponin I