Literature summary for 3.4.23.15 extracted from

Kushiro, T.; Itakura, H.; Abo, Y.; Gotou, H.; Terao, S.; Keefe, D.L.
Long-term safety, tolerability, and antihypertensive efficacy of aliskiren, an oral direct renin inhibitor, in Japanese patients with hypertension (2009), Hypertens. Res., 32, 169-175.

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Application

Application	Comment	Organism
pharmacology	study on long-term safety, tolerability, and antihypertensive efficacy on Japanese patients with mild to moderate essential hypertension. Aliskiren alone or in combination with a diuretic or a calcium channel blocker is well tolerated. The incidence of suspected study-related adverse events was 25.3%. The overall responder efficacy was 73.3% at the endpoint. A clinically meaningful reduction of 17.6/12.8 m Hg from baseline was achieved in the mean sitting blood pressure at the endpoint	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
aliskiren	study on long-term safety, tolerability, and antihypertensive efficacy on Japanese patients with mild to moderate essential hypertension. Aliskiren alone or in combination with a diuretic or a calcium channel blocker is well tolerated. The incidence of suspected study-related adverse events was 25.3%. The overall responder efficacy was 73.3% at the endpoint. A clinically meaningful reduction of 17.6/12.8 m Hg from baseline was achieved in the mean sitting blood pressure at the endpoint	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with hypertension	-

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Release 2023.1 (January 2023)