Literature summary for 3.4.23.15 extracted from

Lastra, G.; Habibi, J.; Whaley-Connell, A.T.; Manrique, C.; Hayden, M.R.; Rehmer, J.; Patel, K.; Ferrario, C.; Sowers, J.R.
Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression (2009), Endocrinology, 150, 2561-2568.

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Application

Application	Comment	Organism
medicine	renin inhibition improves systemic insulin sensitivity, insulin metabolic signaling and glucose transport, along with normalization of angiotensin II, angiotensin type I receptor and mineralocorticoid receptor levels, oxidative stress markers, fibrosis and mitochondrial structural abnormalities	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	treatment of transgenic Ren2 rat results in systemic insulin resistance with decreased skeletal muscle insulin metabolic signaling and glucose uptake. Effects are associated with increased angiotensin II, mineralocorticoid receptor, angiotensin type I receptor, oxidative stress, and reduced tyrosine insulin receptor substrate phosphorylation, protein kinase B/(Akt) phosphorylation and GLUT-4 immunostaining	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
aliskiren	treatment of transgenic Ren2 rat results in systemic insulin resistance with decreased skeletal muscle insulin metabolic signaling and glucose uptake. Effects are associated with increased angiotensin II, mineralocorticoid receptor, angiotensin type I receptor, oxidative stress, and reduced tyrosine insulin receptor substrate phosphorylation, protein kinase B/(Akt) phosphorylation and GLUT-4 immunostaining	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	transgenic expression in Ren2 rat	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

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Release 2023.1 (January 2023)