Cloned (Comment) | Organism |
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transgenic expression in Ren2 rat | Mus musculus |
Protein Variants | Comment | Organism |
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additional information | transgenic expression in Ren2 rat results in hypertension, insulin resistance, and cardiovascular damage. Treatment of young heterozygous male Ren2 and age-matched control rats with renin inhibitor aliskiren leads to significantly increased blood pressure, NADPH oxidase activity and subunit immunostaining, 3-nitrotyrosine, perivascular fibrosis, mitochondrial content and markers of activity in Ren2 rats. Both renin inhibition and blockade of the Ang I type receptor significantly attenuate cardiac functional and structural alterations | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aliskiren | treatment of young heterozygous male Ren2 and age-matched control rats with renin inhibitor aliskiren leads to significantly increased blood pressure, NADPH oxidase activity and subunit immunostaining, 3-nitrotyrosine, perivascular fibrosis, mitochondrial content and markers of activity in Ren2 rats | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
transgenic expression in rat | - |
Source Tissue | Comment | Organism | Textmining |
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