Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.23.15 extracted from

  • Whaley-Connell, A.; Habibi, J.; Cooper, S.A.; Demarco, V.G.; Hayden, M.R.; Stump, C.S.; Link, D.; Ferrario, C.M.; Sowers, J.R.
    Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat (2008), Am. J. Physiol. Endocrinol. Metab., 295, E103-E109.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
transgenic expression in Ren2 rat Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information transgenic expression in Ren2 rat results in hypertension, insulin resistance, and cardiovascular damage. Treatment of young heterozygous male Ren2 and age-matched control rats with renin inhibitor aliskiren leads to significantly increased blood pressure, NADPH oxidase activity and subunit immunostaining, 3-nitrotyrosine, perivascular fibrosis, mitochondrial content and markers of activity in Ren2 rats. Both renin inhibition and blockade of the Ang I type receptor significantly attenuate cardiac functional and structural alterations Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
aliskiren treatment of young heterozygous male Ren2 and age-matched control rats with renin inhibitor aliskiren leads to significantly increased blood pressure, NADPH oxidase activity and subunit immunostaining, 3-nitrotyrosine, perivascular fibrosis, mitochondrial content and markers of activity in Ren2 rats Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
transgenic expression in rat
-

Source Tissue

Source Tissue Comment Organism Textmining