Literature summary for 3.4.22.B79 extracted from

Sun, Z.; Li, Y.; Ransburgh, R.; Snijder, E.J.; Fang, Y.
Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15 (2012), J. Virol., 86, 3839-3850.

Search for more literature for 3.4.22.B79

Application

Application	Comment	Organism
medicine	ubiquitin-like protein ISG15 overexpression inhibits porcine reproductive and respiratory syndrome virus replication in cell culture and the antiviral activity of interferon is reduced by inhibition of ISG15 conjugation. Nonstructural protein nsp2 is a key factor in counteracting the antiviral function of ISG15	porcine reproductive and respiratory syndrome virus

Protein Variants

Protein Variants	Comment	Organism
additional information	mutants with deletions and/or mutations at the N-terminal border of the nsp2 PLP2-DUB domain. A 23-amino-acid deletion of amino acids 402 to 424 of the ORF1a-encoded protein largely abolishes the inhibitory effect of nsp2 on ubiquitin-like protein ISG15 production and conjugation, but no viable recombinant virus is recovered. A 19-amino-acid deletion of amino acids 402 to 420, in combination with downstream point mutation S465A, partially relieves the ISG15 antagonist function and yields a viable recombinant virus	porcine reproductive and respiratory syndrome virus

Organism

Organism	UniProt	Comment	Textmining
porcine reproductive and respiratory syndrome virus	-	-	-

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Release 2023.1 (January 2023)