Protein Variants | Comment | Organism |
---|---|---|
C481G | mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal | Sindbis virus |
C481R | mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal | Sindbis virus |
C481S | mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal | Sindbis virus |
C525R | mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal | Sindbis virus |
C525S | mutant is active and processed normally | Sindbis virus |
H558A | mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal | Sindbis virus |
H558Q | mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal | Sindbis virus |
H558Y | mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal | Sindbis virus |
H619A | mutant is active and processed normally | Sindbis virus |
H701A | mutant is active and processed normally | Sindbis virus |
H709A | mutant is active and processed normally | Sindbis virus |
H709R | mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal | Sindbis virus |
H709Y | mutant is active and processed normally | Sindbis virus |
N561D | mutant shows some activity, with normal processing | Sindbis virus |
N561S | mutant shows some activity, with normal processing | Sindbis virus |
N609D | mutant is active, almost no processing | Sindbis virus |
N609S | mutant is active, with reduced processing | Sindbis virus |
N614D | mutant shows enhanced processing, and is lethal | Sindbis virus |
N614S | mutant shows some activity, with normal processing | Sindbis virus |
N693S | mutant shows some activity, and is lethal | Sindbis virus |
S535T | mutant is active and processed normally | Sindbis virus |
Y559A | mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal | Sindbis virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sindbis virus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the catalytic dyad is composed of Cys-481 and His-558 | Sindbis virus | ? | - |
? | |
Sindbis virus core protein + H2O | - |
Sindbis virus | Hydrolyzed Sindbis core protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
non-structural polyprotein 2 | - |
Sindbis virus |
nsP2 | - |
Sindbis virus |