Literature summary for 3.4.22.B75 extracted from

Cui, Y.; Yu, H.; Zheng, X.; Peng, R.; Wang, Q.; Zhou, Y.; Wang, R.; Wang, J.; Qu, B.; Shen, N.; Guo, Q.; Liu, X.; Wang, C.
SENP7 potentiates cGAS activation by relieving SUMO-mediated inhibition of cytosolic DNA sensing (2017), PLoS Pathog., 13, e1006156 .

Search for more literature for 3.4.22.B75

Application

Application	Comment	Organism
medicine	SENP7 is significantly up-regulated in patients with systemic lupus erythematosus	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BQF6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
THP-1 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(K335, K372, K382)-triSUMOyl-cyclic GMP-AMP synthase + 3 H2O	SUMO is conjugated onto the lysine residues 335, 372 and 382. SENP7 reverses this inhibition via catalyzing the deSUMOylation	Homo sapiens	3 SUMO + cyclic GMP-AMP synthase	-	?

General Information

General Information	Comment	Organism
physiological function	SENP7 interacted with and potentiated cyclic GMP-AMP synthase cGAS activation. The small ubiquitin-like modifier (SUMO) is conjugated onto the lysine residues 335, 372 and 382 of cGAS, which suppresses its DNA-binding, oligomerization and nucleotidyl-transferase activities. SENP7 reverses this inhibition via catalyzing the cGAS de-SUMOylation. Silencing of SENP7 markedly impaires the IRF3-responsive gene expression induced by cGAS-STING axis	Homo sapiens

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Release 2023.1 (January 2023)