Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8BUH8 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oocyte | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | mouse oocytes deficient in SENP7 experienced meiotic arrest at prophase I and metaphase I stages. SENP7 depletion compromises oocyte meiosis. Aberrant epigenetic marks on histone H3 and disrupted expression of germinal vesicle breakdown-related proteins intervene M-phase entry in SENP7-depleted oocytes. SENP7-dependent microtubule organizing centers function is essential for spindle assembly. The resulting changes on histone H3 restrict Rad51C loading onto DNA lesions due to elevated HP1alpha euchromatic deposition, and reduced DNA 5hmC challenges the permissive status for zygotic DNA repair, which induce embryo death | Mus musculus |