Literature summary for 3.4.22.B75 extracted from

Ji, P.; Liang, S.; Li, P.; Xie, C.; Li, J.; Zhang, K.; Zheng, X.; Feng, M.; Li, Q.; Jiao, H.; Chi, X.; Zhao, W.; Zhang, S.; Wang, X.
Speckle-type POZ protein suppresses hepatocellular carcinoma cell migration and invasion via ubiquitin-dependent proteolysis of SUMO1/sentrin specific peptidase 7 (2018), Biochem. Biophys. Res. Commun., 502, 30-42 .

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Application

Application	Comment	Organism
medicine	increased degradation of SENP7 by overexpression of SPOP decreases vimentin levels, which in turn may attenuate hepatocellular carcinoma cell metastasis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BQF6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatoma cell	-	Homo sapiens	-
liver	-	Homo sapiens	-

General Information

General Information	Comment	Organism
metabolism	speckle-type POZ protein (SPOP) expression is significantly downregulated in hepatocellular carcinoma and is associated with tumor size, differentiation and metastasis. SPOP recognizes and binds SENP7 and promotes its degradation via ubiquitin-dependent proteolysis. Vimentin expression is correlated negatively with SPOP and positively with SENP7	Homo sapiens

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Release 2023.1 (January 2023)