BRENDA - Enzyme Database show
show all sequences of 3.4.22.B74

The SUMO protease SENP6 is a direct regulator of PML nuclear bodies

Hattersley, N.; Shen, L.; Jaffray, E.G.; Hay, R.T.; Mol. Biol. Cell 22, 78-90 (2010)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
SUMO-modified promyelocytic leukemia protein + H2O
Homo sapiens
-
SUMO + promyelocytic leukemia protein
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-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q9GZR1
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
although SUMO-2/3 chains are the preferred substrate, SENP6 is also capable of cleaving mixed chains of SUMO-1 and SUMO-2/3
716169
Homo sapiens
?
-
-
-
-
SUMO-modified promyelocytic leukemia protein + H2O
-
716169
Homo sapiens
SUMO + promyelocytic leukemia protein
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
SUMO-modified promyelocytic leukemia protein + H2O
Homo sapiens
-
SUMO + promyelocytic leukemia protein
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
although SUMO-2/3 chains are the preferred substrate, SENP6 is also capable of cleaving mixed chains of SUMO-1 and SUMO-2/3
716169
Homo sapiens
?
-
-
-
-
SUMO-modified promyelocytic leukemia protein + H2O
-
716169
Homo sapiens
SUMO + promyelocytic leukemia protein
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
depletion of SENP6 results in accumulation of endogenous SUMO-2/3 and SUMO-1 conjugates, and in accumulation of SUMO and promyelocytic leukemia protein in an increased number of promyelocytic leukemia nuclear bodies. Although SENP6 depletion drastically increases the size of promyelocytic leukemia nuclear bodies, the organizational structure of the body is not affected
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
malfunction
depletion of SENP6 results in accumulation of endogenous SUMO-2/3 and SUMO-1 conjugates, and in accumulation of SUMO and promyelocytic leukemia protein in an increased number of promyelocytic leukemia nuclear bodies. Although SENP6 depletion drastically increases the size of promyelocytic leukemia nuclear bodies, the organizational structure of the body is not affected
Homo sapiens
Other publictions for EC 3.4.22.B74
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
732884
Alegre
Structural insights into the S ...
Homo sapiens
Protein Sci.
23
433-441
2014
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1
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2
2
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715706
Mukhopadhyay
The SUMO protease SENP6 is ess ...
Homo sapiens
J. Cell Biol.
188
681-692
2010
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2
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716169
Hattersley
The SUMO protease SENP6 is a d ...
Homo sapiens
Mol. Biol. Cell
22
78-90
2010
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1
1
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714081
Drag
Activity profiling of human de ...
Homo sapiens
Biochem. J.
409
461-469
2008
2
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1
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715494
Lima
Structure of the human SENP7 c ...
Homo sapiens
J. Biol. Chem.
283
32045-32055
2008
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8
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715444
Kim
A new SUMO-1-specific protease ...
Homo sapiens
J. Biol. Chem.
275
14102-14106
2000
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1
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