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Literature summary for 3.4.22.B74 extracted from

  • Lima, C.D.; Reverter, D.
    Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7 (2008), J. Biol. Chem., 283, 32045-32055.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9GZR1
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(SUMO-3)-Ran GTPase-activating protein 1 conjugate + H2O SENP6 and SENP7 prefer SUMO2 or SUMO3 in deconjugation reactions with rates comparable with those catalyzed by SENP2. In contrast to SENP2, SENP6 and SENP7 are less able to deconjugate SUMO1-RanGAP1, and products are only detected at enzyme concentrations 100 x higher than that observed for reactions containing SENP2 Homo sapiens SUMO-3 + Ran GTPase-activating protein 1
-
?
di-SUMO-2 + H2O
-
Homo sapiens 2 SUMO-2
-
?
di-SUMO-3 + H2O
-
Homo sapiens 2 SUMO-3
-
?
poly-SUMO-2 + H2O
-
Homo sapiens ?
-
?
poly-SUMO-3 + H2O
-
Homo sapiens ?
-
?
SUMO-1 precursor + H2O SENP6 exhibits lower rates for processing pre-SUMO-1, pre-SUMO-2, or pre-SUMO3 in comparison with SENP2 Homo sapiens SUMO-1 + His-Ser-Thr-Val
-
?
SUMO-2 precursor + H2O SENP6 exhibits lower rates for processing pre-SUMO-1, pre-SUMO-2, or pre-SUMO3 in comparison with SENP2 Homo sapiens SUMO-2 + Val-Tyr
-
?
SUMO-3 precursor + H2O SENP6 exhibits lower rates for processing pre-SUMO-1, pre-SUMO-2, or pre-SUMO-3 in comparison with SENP2 Homo sapiens SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
-
?

Synonyms

Synonyms Comment Organism
SENP6
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
23
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens