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show all sequences of 3.4.22.B74

Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7

Lima, C.D.; Reverter, D.; J. Biol. Chem. 283, 32045-32055 (2008)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q9GZR1
-
-
Purification (Commentary)
Commentary
Organism
-
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(SUMO-3)-Ran GTPase-activating protein 1 conjugate + H2O
SENP6 and SENP7 prefer SUMO2 or SUMO3 in deconjugation reactions with rates comparable with those catalyzed by SENP2. In contrast to SENP2, SENP6 and SENP7 are less able to deconjugate SUMO1-RanGAP1, and products are only detected at enzyme concentrations 100 x higher than that observed for reactions containing SENP2
715494
Homo sapiens
SUMO-3 + Ran GTPase-activating protein 1
-
-
-
?
di-SUMO-2 + H2O
-
715494
Homo sapiens
2 SUMO-2
-
-
-
?
di-SUMO-3 + H2O
-
715494
Homo sapiens
2 SUMO-3
-
-
-
?
poly-SUMO-2 + H2O
-
715494
Homo sapiens
?
-
-
-
?
poly-SUMO-3 + H2O
-
715494
Homo sapiens
?
-
-
-
?
SUMO-1 precursor + H2O
SENP6 exhibits lower rates for processing pre-SUMO-1, pre-SUMO-2, or pre-SUMO3 in comparison with SENP2
715494
Homo sapiens
SUMO-1 + His-Ser-Thr-Val
-
-
-
?
SUMO-2 precursor + H2O
SENP6 exhibits lower rates for processing pre-SUMO-1, pre-SUMO-2, or pre-SUMO3 in comparison with SENP2
715494
Homo sapiens
SUMO-2 + Val-Tyr
-
-
-
?
SUMO-3 precursor + H2O
SENP6 exhibits lower rates for processing pre-SUMO-1, pre-SUMO-2, or pre-SUMO-3 in comparison with SENP2
715494
Homo sapiens
SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
23
-
assay at
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(SUMO-3)-Ran GTPase-activating protein 1 conjugate + H2O
SENP6 and SENP7 prefer SUMO2 or SUMO3 in deconjugation reactions with rates comparable with those catalyzed by SENP2. In contrast to SENP2, SENP6 and SENP7 are less able to deconjugate SUMO1-RanGAP1, and products are only detected at enzyme concentrations 100 x higher than that observed for reactions containing SENP2
715494
Homo sapiens
SUMO-3 + Ran GTPase-activating protein 1
-
-
-
?
di-SUMO-2 + H2O
-
715494
Homo sapiens
2 SUMO-2
-
-
-
?
di-SUMO-3 + H2O
-
715494
Homo sapiens
2 SUMO-3
-
-
-
?
poly-SUMO-2 + H2O
-
715494
Homo sapiens
?
-
-
-
?
poly-SUMO-3 + H2O
-
715494
Homo sapiens
?
-
-
-
?
SUMO-1 precursor + H2O
SENP6 exhibits lower rates for processing pre-SUMO-1, pre-SUMO-2, or pre-SUMO3 in comparison with SENP2
715494
Homo sapiens
SUMO-1 + His-Ser-Thr-Val
-
-
-
?
SUMO-2 precursor + H2O
SENP6 exhibits lower rates for processing pre-SUMO-1, pre-SUMO-2, or pre-SUMO3 in comparison with SENP2
715494
Homo sapiens
SUMO-2 + Val-Tyr
-
-
-
?
SUMO-3 precursor + H2O
SENP6 exhibits lower rates for processing pre-SUMO-1, pre-SUMO-2, or pre-SUMO-3 in comparison with SENP2
715494
Homo sapiens
SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
23
-
assay at
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Homo sapiens
Other publictions for EC 3.4.22.B74
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
732884
Alegre
Structural insights into the S ...
Homo sapiens
Protein Sci.
23
433-441
2014
-
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1
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1
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1
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-
2
2
-
-
-
715706
Mukhopadhyay
The SUMO protease SENP6 is ess ...
Homo sapiens
J. Cell Biol.
188
681-692
2010
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1
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2
2
-
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716169
Hattersley
The SUMO protease SENP6 is a d ...
Homo sapiens
Mol. Biol. Cell
22
78-90
2010
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1
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1
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1
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2
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1
1
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714081
Drag
Activity profiling of human de ...
Homo sapiens
Biochem. J.
409
461-469
2008
2
-
1
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1
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1
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1
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3
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1
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1
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715494
Lima
Structure of the human SENP7 c ...
Homo sapiens
J. Biol. Chem.
283
32045-32055
2008
-
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-
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-
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1
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1
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8
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1
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1
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1
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8
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1
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1
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715444
Kim
A new SUMO-1-specific protease ...
Homo sapiens
J. Biol. Chem.
275
14102-14106
2000
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1
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1
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1
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4
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9
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3
1
1
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1
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1
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1
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1
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9
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3
1
1
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1
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