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Literature summary for 3.4.22.B70 extracted from

  • Chow, K.H.; Elgort, S.; Dasso, M.; Ullman, K.S.
    Two distinct sites in Nup153 mediate interaction with the SUMO proteases SENP1 and SENP2 (2012), Nucleus, 3, 349-358.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B70

Cloned(Commentary)

Cloned (Comment) Organism
gene SP1, recombinant expression of GFP-tagged or untagged SENP1 and the catalytically dead enzyme mutant transiently in HeLa cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nuclear envelope
-
 Homo sapiens 5635
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens nucleoporin Nup153 binds to SENP1 by interacting with the unique N-terminal domain of Nup153 as well as a specific region within the C-terminal FG-rich region. Nup153 is a substrate for SUMOylation, with this modification kept in check by the SUMO protease ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information nucleoporin Nup153 binds to SENP1 by interacting with the unique N-terminal domain of Nup153 as well as a specific region within the C-terminal FG-rich region. Nup153 is a substrate for SUMOylation, with this modification kept in check by the SUMO protease Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
SENP1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens SENP1 levels are influenced by the presence of nucleoporin Nup153 additional information

General Information

General Information Comment Organism
malfunction specifically, either RNAi depletion of SENP1/SENP2 or expression of dominantly interfering mutants of these proteins results in increased sumoylation of endogenous Nup153. Catalytically inactive SENP1 maintains specific attributes, although it has enhanced interaction with sumoylated Nup153, overview. Truncated SENP1CD is modified by both SUMO1 and SUMO2 Homo sapiens
additional information SENP1 is a target of SUMO modification and has targeting preference for SUMO paralogues and substrates Homo sapiens
physiological function the SUMO proteases play roles both in processing SUMO during the biogenesis of this peptide moiety and also in reversing SUMO modification on specific targets to control the activities conferred by this posttranslational modification. Specificity of the role for SENP1 and SENP2 in maintaining desumoylation of Nup153 Homo sapiens