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Literature summary for 3.4.22.B70 extracted from
- SENP1 and SENP2 affect spatial and temporal control of sumoylation in mitosis (2013), Mol. Biol. Cell, 24, 3483-3495.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of GFP-tagged SENP2 in HeLa cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | the enzyme SENP1 is targeted to kinetochores in mitosis | Homo sapiens | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9P0U3 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SENP1 | - |
Homo sapiens |
| small ubiquitin-related modifier-specific isopeptidase | - |
Homo sapiens |
| SUMO-specific isopeptidase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | RNA interference-mediated knockdown of SENP1 delays sister chromatid separation at metaphase | Homo sapiens |
| physiological function | enzyme SENP1 is an important mediator of precise spatial and temporal control of sumoylation in mitosis required for chromosome segregation | Homo sapiens |
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