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Literature summary for 3.4.22.B70 extracted from

  • Yan, X.M.; Xu, Z.Q.; Zhou, Y.; Wang, J.; Pan, J.; Yuan, L.Q.; Fu, M.C.; Xia, H.L.; Cao, X.; Zhang, T.
    SENP1 regulates cell migration and invasion in neuroblastoma (2016), Biotechnol. Appl. Biochem., 63, 435-440.
    View publication on PubMed
Search for more literature for 3.4.22.B70

Application

Application Comment Organism
diagnostics enzyme SENP1 is an important cancer metastasis-related molecule and may be a prognostic marker and a therapeutic target for metastasis in prostate cancer patients Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
GI-LA-N cell
-
 Homo sapiens
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neuroblastoma cell metastatic neuroblastoma tissue Homo sapiens
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SK-N-SH cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
SENP1
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 Homo sapiens
SUMO protease
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 Homo sapiens

General Information

General Information Comment Organism
malfunction the enzyme SENP1 inhibition by siRNA significantly suppresses neuroblastoma cell migration and invasion, overexpression of SENP1 promotes neuroblastoma cells migration and invasion Homo sapiens
physiological function the SUMO protease SENP1 regulates cell migration and invasion in neuroblastoma and can regulate the expression of CDH1, MMP9 and MMP2, overview. SUMO proteases remove SUMO, i.e. small ubiquitin-like modifier, conjugate from proteins, and their expression is deregulated in diverse cancers. SUMOylation and deSUMOylation are dynamic mechanisms regulating a spectrum of protein activities Homo sapiens