Literature summary for 3.4.22.B70 extracted from

Chen, Y.; Wen, D.; Huang, Z.; Huang, M.; Luo, Y.; Liu, B.; Lu, H.; Wu, Y.; Peng, Y.; Zhang, J.
2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation (2012), Bioorg. Med. Chem. Lett., 22, 6867-6870.

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Application

Application	Comment	Organism
drug development	the enzyme is a drug target for development of small molecule drugs against prostate cancer	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
2-(4-chlorophenyl)-2-oxoethyl 4-(benzoylamino)benzoate	-	Homo sapiens
2-(4-chlorophenyl)-2-oxoethyl 4-[(3,4-diethoxybenzoyl)amino]benzoate	-	Homo sapiens
2-(4-chlorophenyl)-2-oxoethyl 4-[(3,4-dimethoxybenzoyl)amino]benzoate	-	Homo sapiens
2-(4-chlorophenyl)-2-oxoethyl 4-[(3-aminobenzoyl)amino]benzoate	-	Homo sapiens
2-(4-chlorophenyl)-2-oxoethyl 4-[(3-fluorobenzoyl)amino]benzoate	-	Homo sapiens
2-(4-chlorophenyl)-2-oxoethyl 4-[(3-hydroxybenzoyl)amino]benzoate	-	Homo sapiens
2-(4-chlorophenyl)-2-oxoethyl 4-[(3-methoxybenzoyl)amino]benzoate	-	Homo sapiens
2-(4-chlorophenyl)-2-oxoethyl 4-[[3-(benzyloxy)benzoyl]amino]benzoate	-	Homo sapiens
additional information	2-(4-chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, evaluation of a class of SENP1 inhibitors by virtual screening, synthesis and biological evaluation, structure-activity relationship, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
prostate cancer cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
SENP1	-	Homo sapiens
sentrin/SUMO-specific protease 1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the enzyme plays an important role in the occurrence and development of prostate cancer	Homo sapiens

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Release 2023.1 (January 2023)