Literature summary for 3.4.22.B70 extracted from

Plant, L.D.; Dementieva, I.S.; Kollewe, A.; Olikara, S.; Marks, J.D.; Goldstein, S.A.
One SUMO is sufficient to silence the dimeric potassium channel K2P1 (2010), Proc. Natl. Acad. Sci. USA, 107, 10743-10748.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(SUMO-1)-K2P1 potassium channel + H2O	Homo sapiens	silent K2P1 channels in excised plasma membrane patches are activated by SENP1	SUMO-1 + K2P1 potassium channel	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9P0U3	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(SUMO-1)-K2P1 potassium channel + H2O	silent K2P1 channels in excised plasma membrane patches are activated by SENP1	Homo sapiens	SUMO-1 + K2P1 potassium channel	-	?
(SUMO-1)-K2P1 subunit of potassium channel + H2O	SUMO1 is conjugated to the epsilon-amino group of Lys274 of the K2P1 potassium channel. When mutated to Gln, Arg, Glu, Asp, Cys, or Ala, the channels are constitutively active and insensitive to SUMO1 and SENP1. Wild-type channels in plasma membrane have two K2P1 subunits and assemble with two SUMO1 monomers. Although channels engineered with one Lys274 site carry just one SUMO1 they are activated and silenced by SENP1 and SUMO1 like wild-type channels	Homo sapiens	SUMO-1 + K2P1 subunit of potassium channel	-	?

Synonyms

Synonyms	Comment	Organism
SUMO isopeptidase	-	Homo sapiens

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Release 2023.1 (January 2023)