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Literature summary for 3.4.22.B70 extracted from

  • Yu, L.; Ji, W.; Zhang, H.; Renda, M.J.; He, Y.; Lin, S.; Cheng, E.C.; Chen, H.; Krause, D.S.; Min, W.
    SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis (2010), J. Exp. Med., 207, 1183-1195.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
SUMO-GATA 1 conjugate + H2O Mus musculus SENP1 promotes GATA1 activation and subsequent erythropoiesis by deSUMOylating GATA1 SUMO + GATA1
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Organism

Organism UniProt Comment Textmining
Mus musculus P59110
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SUMO-GATA 1 conjugate + H2O
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 Mus musculus SUMO + GATA1
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SUMO-GATA 1 conjugate + H2O SENP1 promotes GATA1 activation and subsequent erythropoiesis by deSUMOylating GATA1 Mus musculus SUMO + GATA1
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General Information

General Information Comment Organism
malfunction creation of SENP1 knockout mice based on a Cre-loxP system. Global deletion of SENP1 causes anemia and embryonic lethality between embryonic day 13.5 and postnatal day 1, correlating with erythropoiesis defects in the fetal liver Mus musculus