Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,3'-(3,7,12,17-tetramethylporphyrin-2,18-diyl)dipropanoic acid | - |
Plasmodium falciparum | |
bilirubin | - |
Plasmodium falciparum | |
coproporphyrin | - |
Plasmodium falciparum | |
deuteroporphyrin IX 2,4 (4,2) hydroxyvinyl | - |
Plasmodium falciparum | |
deuteroporphyrin IX 2-vinyl, 4-hydroxymethyl | - |
Plasmodium falciparum | |
heme | heme inhibits falcipain-2 activity against both human hemoglobin and chromogenic peptide substrates through a noncompetitive-like mechanism | Plasmodium falciparum | |
isohematoporphyrin IX | - |
Plasmodium falciparum | |
mesoporphyrin IX dimethyl ester | - |
Plasmodium falciparum | |
N-methyl mesoporphyrin | - |
Plasmodium falciparum | |
N-methyl protoporphyrin IX | - |
Plasmodium falciparum | |
protoporphyrin IX | - |
Plasmodium falciparum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
food vacuole | - |
Plasmodium falciparum | 20020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Hemoglobin + H2O | Plasmodium falciparum | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
nickel affinity column chromatography and Q Sepharose column chromatography | Plasmodium falciparum |
Renatured (Comment) | Organism |
---|---|
- |
Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Hemoglobin + H2O | - |
Plasmodium falciparum | ? | - |
? | |
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Plasmodium falciparum | Z-Phe-Arg + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FP-2 | - |
Plasmodium falciparum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | 6 | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00037 | - |
at pH 5.5 and 37°C | Plasmodium falciparum | N-methyl protoporphyrin IX | |
0.00048 | - |
at pH 5.5 and 37°C | Plasmodium falciparum | deuteroporphyrin IX 2,4 (4,2) hydroxyvinyl | |
0.000515 | - |
at pH 5.5 and 37°C | Plasmodium falciparum | heme | |
0.00055 | - |
at pH 5.5 and 37°C | Plasmodium falciparum | protoporphyrin IX | |
0.00062 | - |
at pH 5.5 and 37°C | Plasmodium falciparum | deuteroporphyrin IX 2-vinyl, 4-hydroxymethyl | |
0.0009 | - |
at pH 5.5 and 37°C | Plasmodium falciparum | coproporphyrin | |
0.002 | - |
at pH 5.5 and 37°C | Plasmodium falciparum | 3,3'-(3,7,12,17-tetramethylporphyrin-2,18-diyl)dipropanoic acid | |
0.002 | - |
at pH 5.5 and 37°C | Plasmodium falciparum | isohematoporphyrin IX | |
0.003 | - |
at pH 5.5 and 37°C | Plasmodium falciparum | bilirubin | |
0.005 | - |
IC50 above 0.005 mM, at pH 5.5 and 37°C | Plasmodium falciparum | N-methyl mesoporphyrin | |
0.005 | - |
IC50 above 0.005 mM, at pH 5.5 and 37°C | Plasmodium falciparum | mesoporphyrin IX dimethyl ester |