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Literature summary for 3.4.22.B69 extracted from

  • Marques, A.F.; Gomes, P.S.; Oliveira, P.L.; Rosenthal, P.J.; Pascutti, P.G.; Lima, L.M.
    Allosteric regulation of the Plasmodium falciparum cysteine protease falcipain-2 by heme (2015), Arch. Biochem. Biophys., 573, 92-99.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
3,3'-(3,7,12,17-tetramethylporphyrin-2,18-diyl)dipropanoic acid
-
Plasmodium falciparum
bilirubin
-
Plasmodium falciparum
coproporphyrin
-
Plasmodium falciparum
deuteroporphyrin IX 2,4 (4,2) hydroxyvinyl
-
Plasmodium falciparum
deuteroporphyrin IX 2-vinyl, 4-hydroxymethyl
-
Plasmodium falciparum
heme heme inhibits falcipain-2 activity against both human hemoglobin and chromogenic peptide substrates through a noncompetitive-like mechanism Plasmodium falciparum
isohematoporphyrin IX
-
Plasmodium falciparum
mesoporphyrin IX dimethyl ester
-
Plasmodium falciparum
N-methyl mesoporphyrin
-
Plasmodium falciparum
N-methyl protoporphyrin IX
-
Plasmodium falciparum
protoporphyrin IX
-
Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
food vacuole
-
Plasmodium falciparum 20020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Hemoglobin + H2O Plasmodium falciparum
-
?
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
nickel affinity column chromatography and Q Sepharose column chromatography Plasmodium falciparum

Renatured (Commentary)

Renatured (Comment) Organism
-
Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hemoglobin + H2O
-
Plasmodium falciparum ?
-
?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
Plasmodium falciparum Z-Phe-Arg + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
FP-2
-
Plasmodium falciparum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 6
-
Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00037
-
at pH 5.5 and 37°C Plasmodium falciparum N-methyl protoporphyrin IX
0.00048
-
at pH 5.5 and 37°C Plasmodium falciparum deuteroporphyrin IX 2,4 (4,2) hydroxyvinyl
0.000515
-
at pH 5.5 and 37°C Plasmodium falciparum heme
0.00055
-
at pH 5.5 and 37°C Plasmodium falciparum protoporphyrin IX
0.00062
-
at pH 5.5 and 37°C Plasmodium falciparum deuteroporphyrin IX 2-vinyl, 4-hydroxymethyl
0.0009
-
at pH 5.5 and 37°C Plasmodium falciparum coproporphyrin
0.002
-
at pH 5.5 and 37°C Plasmodium falciparum 3,3'-(3,7,12,17-tetramethylporphyrin-2,18-diyl)dipropanoic acid
0.002
-
at pH 5.5 and 37°C Plasmodium falciparum isohematoporphyrin IX
0.003
-
at pH 5.5 and 37°C Plasmodium falciparum bilirubin
0.005
-
IC50 above 0.005 mM, at pH 5.5 and 37°C Plasmodium falciparum N-methyl mesoporphyrin
0.005
-
IC50 above 0.005 mM, at pH 5.5 and 37°C Plasmodium falciparum mesoporphyrin IX dimethyl ester