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Literature summary for 3.4.22.B69 extracted from

  • Ehmke, V.; Kilchmann, F.; Heindl, C.; Cui, K.; Huang, J.; Schirmeister, T.; Diederich, F.
    Peptidomimetic nitriles as selective inhibitors for the malarial cysteine protease falcipain-2 (2011), MedChemComm, 2, 800-804.
No PubMed abstract available
Search for more literature for 3.4.22.B69

Inhibitors

Inhibitors Comment Organism Structure
benzyl (1-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]cyclohexyl)carbamate
-
 Plasmodium falciparum
benzyl [1-[(2-oxoethyl)carbamoyl]cyclohexyl]carbamate
-
 Plasmodium falciparum
benzyl [1-[(cyanomethyl)amino]-2-methyl-1-oxopropan-2-yl]carbamate
-
 Plasmodium falciparum
benzyl [1-[(cyanomethyl)carbamoyl]cyclohexyl]carbamate
-
 Plasmodium falciparum
E-64
-
 Plasmodium falciparum
N-(cyanomethyl)-1-([[(1S,2S)-2-phenylcyclopropyl]carbonyl]amino)cyclohexanecarboxamide
-
 Plasmodium falciparum
N-(cyanomethyl)-1-[(3-cyclopentylpropanoyl)amino]cyclohexanecarboxamide
-
 Plasmodium falciparum
N-(cyanomethyl)-1-[(cyclopentylacetyl)amino]cyclohexanecarboxamide
-
 Plasmodium falciparum
N-(cyanomethyl)-1-[[3-(2,3-dimethoxyphenyl)propanoyl]amino]cyclohexanecarboxamide
-
 Plasmodium falciparum
N-(cyanomethyl)-1-[[3-(2-methoxyphenyl)propanoyl]amino]cyclohexanecarboxamide
-
 Plasmodium falciparum
N-(cyanomethyl)-1-[[3-(4-methoxyphenyl)propanoyl]amino]cyclohexanecarboxamide
-
 Plasmodium falciparum
N-(cyanomethyl)-1-[[3-(furan-2-yl)propanoyl]amino]cyclohexanecarboxamide
-
 Plasmodium falciparum
N-(cyanomethyl)-1-[[3-(pyridin-3-yl)propanoyl]amino]cyclohexanecarboxamide
-
 Plasmodium falciparum
N-(cyanomethyl)-1-[[3-(thiophen-2-yl)propanoyl]amino]cyclohexanecarboxamide
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Hemoglobin + H2O Plasmodium falciparum
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q9N6S8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hemoglobin + H2O
-
 Plasmodium falciparum ?
-
 ?

Synonyms

Synonyms Comment Organism
falcipain 2
-
 Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000065
-
 benzyl [1-[(2-oxoethyl)carbamoyl]cyclohexyl]carbamate pH and temperature not specified in the publication Plasmodium falciparum
0.0012
-
 benzyl [1-[(cyanomethyl)carbamoyl]cyclohexyl]carbamate pH and temperature not specified in the publication Plasmodium falciparum
0.0021
-
 N-(cyanomethyl)-1-([[(1S,2S)-2-phenylcyclopropyl]carbonyl]amino)cyclohexanecarboxamide pH and temperature not specified in the publication Plasmodium falciparum
0.0052
-
 N-(cyanomethyl)-1-[[3-(2-methoxyphenyl)propanoyl]amino]cyclohexanecarboxamide pH and temperature not specified in the publication Plasmodium falciparum
0.0073
-
 N-(cyanomethyl)-1-[[3-(2,3-dimethoxyphenyl)propanoyl]amino]cyclohexanecarboxamide pH and temperature not specified in the publication Plasmodium falciparum
0.0076
-
 N-(cyanomethyl)-1-[(cyclopentylacetyl)amino]cyclohexanecarboxamide pH and temperature not specified in the publication Plasmodium falciparum
0.0082
-
 N-(cyanomethyl)-1-[(3-cyclopentylpropanoyl)amino]cyclohexanecarboxamide pH and temperature not specified in the publication Plasmodium falciparum
0.0088
-
 N-(cyanomethyl)-1-[[3-(thiophen-2-yl)propanoyl]amino]cyclohexanecarboxamide pH and temperature not specified in the publication Plasmodium falciparum
0.0089
-
 N-(cyanomethyl)-1-[[3-(4-methoxyphenyl)propanoyl]amino]cyclohexanecarboxamide pH and temperature not specified in the publication Plasmodium falciparum
0.0094
-
 N-(cyanomethyl)-1-[[3-(pyridin-3-yl)propanoyl]amino]cyclohexanecarboxamide pH and temperature not specified in the publication Plasmodium falciparum
0.0172
-
 N-(cyanomethyl)-1-[[3-(furan-2-yl)propanoyl]amino]cyclohexanecarboxamide pH and temperature not specified in the publication Plasmodium falciparum