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Literature summary for 3.4.22.B63 extracted from

  • Marraffini, L.A.; Schneewind, O.
    Targeting proteins to the cell wall of sporulating Bacillus anthracis (2006), Mol. Microbiol., 62, 1402-1417.
    View publication on PubMed
Search for more literature for 3.4.22.B63

Cloned(Commentary)

Cloned (Comment) Organism
SrtCDELTAN (with a replacement of the N-terminal signal peptide of sortase C for six histidy) is expressed in Escherichia coli Bacillus anthracis

Inhibitors

Inhibitors Comment Organism Structure
methylmethane-thiosulphonate hypothesis that the thiol of Cys181 functions as the active site SrtCDELTAN Bacillus anthracis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
BasH polypeptide + H2O Bacillus anthracis sortase C cleaves the LPNTA sorting signal of BasH and BasI, thereby anchoring both polypeptides to the cell wall envelope of sporulating bacilli. Sortase C specifically recognizes and cleaves the LPNTA motif. SrtCDELTAN (with a replacement of the N-terminal signal peptide of sortase C for six histidy) cleaves peptides encompassing the LPNTA motif between threonine and alanine. Sortase C substrate BasH is expressed in the forespore ?
-
 ?
BasI polypeptide + H2O Bacillus anthracis sortase C cleaves the LPNTA sorting signal of BasH and BasI, thereby anchoring both polypeptides to the cell wall envelope of sporulating bacilli. Sortase C specifically recognizes and cleaves the LPNTA motif. SrtCDELTAN (with a replacement of the N-terminal signal peptide of sortase C for six histidy) cleaves peptides encompassing the LPNTA motif between threonine and alanine ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
SrtCDELTAN (with a replacement of the N-terminal signal peptide of sortase C for six histidy) is expressed in Escherichia coli Bacillus anthracis

Source Tissue

Source Tissue Comment Organism Textmining
spore srtC is expressed during sporulation Bacillus anthracis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
BasH polypeptide + H2O sortase C cleaves the LPNTA sorting signal of BasH and BasI, thereby anchoring both polypeptides to the cell wall envelope of sporulating bacilli. Sortase C specifically recognizes and cleaves the LPNTA motif. SrtCDELTAN (with a replacement of the N-terminal signal peptide of sortase C for six histidy) cleaves peptides encompassing the LPNTA motif between threonine and alanine. Sortase C substrate BasH is expressed in the forespore Bacillus anthracis ?
-
 ?
BasH polypeptide + H2O sortase C specifically recognizes and cleaves the BasI LPNTA motif. SrtCDELTAN (with a replacement of the N-terminal signal peptide of sortase C for six histidy) cleaves peptides encompassing the LPNTA motif between threonine and alanine. Sortase C substrate BasH is expressed in the forespore Bacillus anthracis ?
-
 ?
BasI polypeptide + H2O sortase C cleaves the LPNTA sorting signal of BasH and BasI, thereby anchoring both polypeptides to the cell wall envelope of sporulating bacilli. Sortase C specifically recognizes and cleaves the LPNTA motif. SrtCDELTAN (with a replacement of the N-terminal signal peptide of sortase C for six histidy) cleaves peptides encompassing the LPNTA motif between threonine and alanine Bacillus anthracis ?
-
 ?
BasI polypeptide + H2O sortase C specifically recognizes and cleaves the BasI LPNTA motif. SrtCDELTAN (with a replacement of the N-terminal signal peptide of sortase C for six histidy) cleaves peptides encompassing the LPNTA motif between threonine and alanine Bacillus anthracis ?
-
 ?

Synonyms

Synonyms Comment Organism
SrtC
-
 Bacillus anthracis