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Literature summary for 3.4.22.B63 extracted from

  • Marraffini, L.A.; Schneewind, O.
    Sortase C-mediated anchoring of BasI to the cell wall envelope of Bacillus anthracis (2007), J. Bacteriol., 189, 6425-6436.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
BasI polypeptide + H2O Bacillus anthracis the LPNTA motif of BasI is cleaved between the threonine and the alanine residue. The C-terminal carboxyl group of threonine is subsequently amide linked to the side chain amino group of diaminopimelic acid within the wall peptides of Bacillus anthracis peptidoglycan (predivisional cell envelope). Sortase C with an active-site cysteine and the LPNTA sorting signal of BasI are required for anchoring of the polypeptide to the cell wall envelope ?
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Organism

Organism UniProt Comment Textmining
Bacillus anthracis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
BasI polypeptide + H2O the LPNTA motif of BasI is cleaved between the threonine and the alanine residue. The C-terminal carboxyl group of threonine is subsequently amide linked to the side chain amino group of diaminopimelic acid within the wall peptides of Bacillus anthracis peptidoglycan (predivisional cell envelope). Sortase C with an active-site cysteine and the LPNTA sorting signal of BasI are required for anchoring of the polypeptide to the cell wall envelope Bacillus anthracis ?
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BasI polypeptide + H2O the LPNTA motif of BasI polypeptide is cleaved between the threonine and the alanine residue. The C-terminal carboxyl group of threonine is subsequently amide-linked to the side chain amino group of diaminopimelic acid within the wall peptides of Bacillus anthracis peptidoglycan Bacillus anthracis ?
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