Literature summary for 3.4.22.B62 extracted from

Mebius, M.M.; Op Heij, J.M.J.; Tielens, A.G.M.; de Groot, P.G.; Urbanus, R.T.; van Hellemond, J.J.
Fibrinogen and fibrin are novel substrates for Fasciola hepatica cathepsin L peptidases (2018), Mol. Biochem. Parasitol., 221, 10-13 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	the enzyme is secreted	Fasciola hepatica	-	-
extracellular	the enzyme is secreted	Schistosoma mansoni	-	-

Organism

Organism	UniProt	Comment	Textmining
Fasciola hepatica	B3TM67	-	-
Schistosoma mansoni	B4XC67	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Collagen + H2O	-	Fasciola hepatica	?	-	?
Fibrinogen + H2O	FhCL3 demonstrates only minor cleavage of the gamma-chain and slower cleavage of the alpha-chain and beta-chain	Fasciola hepatica	?	-	?
additional information	no activity with fibrinogen or fibrin	Schistosoma mansoni	?	-	?

Synonyms

Synonyms	Comment	Organism
FhCL3	-	Fasciola hepatica
SmCL3	-	Schistosoma mansoni

General Information

General Information	Comment	Organism
physiological function	although no direct anticoagulant effect of the peptidases is observed, cathepsin peptidases from Fasciola are able to degrade purified fibrinogen, with FhCL1 having the highest fibrinogenolytic activity. FhCL1 and FhCL2 also both efficiently degrade fibrin, but FhCL3 does not. FhCL1 has a larger fibrinogenolytic activity than FhCL2 and FhCL3 and is capable of degradation of the fibrinogen alpha-chain, beta-chain, and gamma-chain. FhCL2 andFhCL3 demonstrate only minor cleavage of the gamma-chain and slower cleavage of the alpha-chain and beta-chain compared to FhCL1	Fasciola hepatica
physiological function	schistosomal cathepsin peptidases are not able to cleave fibrinogen or fibrin, which is in line with the presence of other anticoagulant and fibrinolytic strategies adopted by schistosomes. This allows schistosomes to counteract fibrin formation at their surface, allowing blood-feeding and survival of the parasite within its host	Schistosoma mansoni

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Release 2023.1 (January 2023)