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Literature summary for 3.4.22.B49 extracted from

  • Moran, B.W.; Anderson, F.P.; Ruth, D.M.; Fagain, C.O.; Dalton, J.P.; Kenny, P.T.
    Fluorobenzoyl dipeptidyl derivatives as inhibitors of the Fasciola hepatica cysteine protease cathepsin L1 (2010), J. Enzyme Inhib. Med. Chem., 25, 1-12.
    View publication on PubMed
Search for more literature for 3.4.22.B49

Inhibitors

Inhibitors Comment Organism Structure
Benzyloxycarbonyl-Phe-Ala-CHN2
-
 Fasciola hepatica
N-2,3,4,5,6-pentafluorobenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-2,3,4,5-tetrafluorobenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-2,3,4-trifluorobenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-2,3,6-trifluorobenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-2,3-difluorobenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-2,4,5-trifluorobenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-2,4-difluorobenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-2,5-difluorobenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-2,6-difluorobenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-2-fluorobenzoyl-L-alanine-beta-alanine nitrile
-
 Fasciola hepatica
N-2-fluorobenzoyl-L-alanine-glycine nitrile
-
 Fasciola hepatica
N-2-fluorobenzoyl-L-leucine-beta-alanine benzyl ester
-
 Fasciola hepatica
N-2-fluorobenzoyl-L-leucine-beta-alanine nitrile
-
 Fasciola hepatica
N-2-fluorobenzoyl-L-leucine-gamma-aminobutyric acid benzyl ester
-
 Fasciola hepatica
N-2-fluorobenzoyl-L-leucyl-glycine benzyl ester
-
 Fasciola hepatica
N-2-fluorobenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-2-trifluoromethylbenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-3,4,5-trifluorobenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-3,4-difluorobenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-3,5-difluorobenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-3-fluorobenzoyl-L-leucine-beta-alanine benzyl ester
-
 Fasciola hepatica
N-3-fluorobenzoyl-L-leucine-gamma-aminobutyric acid benzyl ester
-
 Fasciola hepatica
N-3-fluorobenzoyl-L-leucyl-glycine benzyl ester
-
 Fasciola hepatica
N-3-fluorobenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-3-trifluoromethylbenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-4-fluorobenzoyl-L-leucine-beta-alanine benzyl ester
-
 Fasciola hepatica
N-4-fluorobenzoyl-L-leucine-beta-alanine nitrile
-
 Fasciola hepatica
N-4-fluorobenzoyl-L-leucine-gamma-aminobutyric acid benzyl ester
-
 Fasciola hepatica
N-4-fluorobenzoyl-L-leucyl-glycine benzyl ester
-
 Fasciola hepatica
N-4-fluorobenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-4-trifluoromethylbenzoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-benzoyl-L-leucyl-glycine
-
 Fasciola hepatica
N-cinnamoyl-L-leucyl-glycine nitrile
-
 Fasciola hepatica
N-pentafluorobenzoyl-L-alanine-beta-alanine nitrile
-
 Fasciola hepatica
N-pentafluorobenzoyl-L-alanine-glycine nitrile
-
 Fasciola hepatica
N-pentafluorobenzoyl-L-leucine-beta-alanine benzyl ester
-
 Fasciola hepatica
N-pentafluorobenzoyl-L-leucine-gamma-aminobutyric acid benzyl ester
-
 Fasciola hepatica
N-pentafluorobenzoyl-L-leucyl-glycine benzyl ester
-
 Fasciola hepatica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Hemoglobin + H2O Fasciola hepatica
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Fasciola hepatica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Fasciola hepatica benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
Hemoglobin + H2O
-
 Fasciola hepatica ?
-
 ?

Synonyms

Synonyms Comment Organism
CL1
-
 Fasciola hepatica

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0028
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-4-fluorobenzoyl-L-leucyl-glycine nitrile
0.003
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica Benzyloxycarbonyl-Phe-Ala-CHN2
0.003
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2-fluorobenzoyl-L-leucyl-glycine nitrile
0.003
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-3,5-difluorobenzoyl-L-leucyl-glycine nitrile
0.0031
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-3-fluorobenzoyl-L-leucyl-glycine nitrile
0.0031
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2,5-difluorobenzoyl-L-leucyl-glycine nitrile
0.0031
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-3,4-difluorobenzoyl-L-leucyl-glycine nitrile
0.0032
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-4-trifluoromethylbenzoyl-L-leucyl-glycine nitrile
0.0034
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2,3-difluorobenzoyl-L-leucyl-glycine nitrile
0.0034
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-3,4,5-trifluorobenzoyl-L-leucyl-glycine nitrile
0.0034
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2,3,4,5-tetrafluorobenzoyl-L-leucyl-glycine nitrile
0.0037
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2,6-difluorobenzoyl-L-leucyl-glycine nitrile
0.0041
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2,3,4-trifluorobenzoyl-L-leucyl-glycine nitrile
0.0041
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2-trifluoromethylbenzoyl-L-leucyl-glycine nitrile
0.0044
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2,3,4,5,6-pentafluorobenzoyl-L-leucyl-glycine nitrile
0.0045
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2,4,5-trifluorobenzoyl-L-leucyl-glycine nitrile
0.0055
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2,4-difluorobenzoyl-L-leucyl-glycine nitrile
0.006
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2,3,6-trifluorobenzoyl-L-leucyl-glycine nitrile
0.0091
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-3-trifluoromethylbenzoyl-L-leucyl-glycine nitrile
0.01
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-benzoyl-L-leucyl-glycine
0.011
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-cinnamoyl-L-leucyl-glycine nitrile
0.0153
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2-fluorobenzoyl-L-leucine-gamma-aminobutyric acid benzyl ester
0.0193
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-4-fluorobenzoyl-L-leucine-gamma-aminobutyric acid benzyl ester
0.0214
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-pentafluorobenzoyl-L-leucine-gamma-aminobutyric acid benzyl ester
0.0216
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-4-fluorobenzoyl-L-leucine-beta-alanine nitrile
0.0243
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2-fluorobenzoyl-L-leucine-beta-alanine nitrile
0.0248
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-3-fluorobenzoyl-L-leucine-beta-alanine benzyl ester
0.0294
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2-fluorobenzoyl-L-leucine-beta-alanine benzyl ester
0.0395
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-pentafluorobenzoyl-L-leucyl-glycine benzyl ester
0.0401
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-3-fluorobenzoyl-L-leucine-gamma-aminobutyric acid benzyl ester
0.0434
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-4-fluorobenzoyl-L-leucyl-glycine benzyl ester
0.0577
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-pentafluorobenzoyl-L-leucine-beta-alanine benzyl ester
0.0623
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-4-fluorobenzoyl-L-leucine-beta-alanine benzyl ester
0.0683
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-pentafluorobenzoyl-L-alanine-glycine nitrile
0.0876
-
 in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2-fluorobenzoyl-L-alanine-glycine nitrile
0.1
-
 IC50 above 0.1 mM, in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2-fluorobenzoyl-L-leucyl-glycine benzyl ester
0.1
-
 IC50 above 0.1 mM, in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-3-fluorobenzoyl-L-leucyl-glycine benzyl ester
0.1
-
 IC50 above 0.1 mM, in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-2-fluorobenzoyl-L-alanine-beta-alanine nitrile
0.1
-
 IC50 above 0.1 mM, in 0.1 M sodium acetate, at 37°C, pH not specified in the publication Fasciola hepatica N-pentafluorobenzoyl-L-alanine-beta-alanine nitrile