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Literature summary for 3.4.22.B49 extracted from

  • Dowd, A.J.; Smith, A.M.; McGonigle, S.; Dalton, J.P.
    Purification and characterization of a second cathepsin L proteinase secreted by parasitic trematode Fasciola hepatica (1994), Eur. J. Biochem., 223, 91-98.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information cathepsin L2 is completely inactivated by 4 mM tetranitromethane, cathepsin L1 is not inactivated Fasciola hepatica

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0054
-
H-Leu-Val-Tyr-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.0054
-
H-Leu-Val-Tyr-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.0093
-
benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.0093
-
benzoyl-Phe-Val-Arg-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.0147
-
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.0147
-
benzyloxycarbonyl-Phe-Arg-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.0204
-
benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.0204
-
benzyloxycarbonyl-Arg-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.026
-
tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.026
-
tosyl-Gly-Pro-Arg-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.0347
-
t-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.0347
-
tert-butyloxycarbonyl-Val-Leu-Lys-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.0385
-
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.0385
-
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.0436
-
t-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.0436
-
tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.0653
-
succinyl-Ala-Phe-Lys-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.0653
-
succinyl-Ala-Phe-Lys-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.0656
-
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.0656
-
benzyloxycarbonyl-Arg-Arg-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.1069
-
tosyl-Gly-Pro-Lys-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.1069
-
tosyl-Gly-Pro-Lys-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Fasciola hepatica cathepsin L1 and cathepsin L2 proteinases may be the prime mechanism by which the parasite penetrates tissue ?
-
?

Organic Solvent Stability

Organic Solvent Comment Organism
Ethanol no inactivation of cathepsin L1 or cathepsin L2 Fasciola hepatica

Organism

Organism UniProt Comment Textmining
Fasciola hepatica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoyl-Phe-Val-Arg-4-methylcoumarinyl-7-amide + H2O cathepsin L1 Fasciola hepatica benzoyl-Phe-Val-Arg + 7-amino-4-methylcoumarin
-
?
benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin + H2O
-
Fasciola hepatica benzoyl-Phe-Val-Arg + 7-amino-4-methylcoumarin
-
?
benzyloxycarbonyl-Arg-4-methylcoumarinyl-7-amide + H2O cathepsin L1 Fasciola hepatica benzyloxycarbonyl-Arg + 7-amino-4-methylcoumarin
-
?
benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin + H2O
-
Fasciola hepatica benzyloxycarbonyl-Arg + 7-amino-4-methylcoumarin
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarinyl-7-amide + H2O cathepsin L1 Fasciola hepatica benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
Fasciola hepatica benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarinyl-7-amide + H2O cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 Fasciola hepatica benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 Fasciola hepatica benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
?
H-Leu-Val-Tyr-4-methylcoumarinyl-7-amide + H2O cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 Fasciola hepatica H-Leu-Val-Tyr + 7-amino-4-methylcoumarin
-
?
H-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
-
Fasciola hepatica H-Leu-Val-Tyr + 7-amino-4-methylcoumarin
-
?
Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 Fasciola hepatica Leu-Val-Tyr + 7-amino-4-methylcoumarin
-
?
additional information cathepsin L1 and cathepsin L2 proteinases may be the prime mechanism by which the parasite penetrates tissue Fasciola hepatica ?
-
?
succinyl-Ala-Phe-Lys-4-methylcoumarinyl-7-amide + H2O cathepsin L1 Fasciola hepatica succinyl-Ala-Phe-Lys + 7-amino-4-methylcoumarin
-
?
succinyl-Ala-Phe-Lys-7-amido-4-methylcoumarin + H2O
-
Fasciola hepatica tosyl-Ala-Phe-Lys + 7-amino-4-methylcoumarin
-
?
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarinyl-7-amide + H2O cathepsin L1 Fasciola hepatica succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
-
?
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
-
Fasciola hepatica succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
-
?
t-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
-
Fasciola hepatica t-butyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin
-
?
t-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 Fasciola hepatica t-butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
-
?
tert-butyloxycarbonyl-Val-Leu-Lys-4-methylcoumarinyl-7-amide + H2O cathepsin L1 Fasciola hepatica tert-butyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin
-
?
tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumarinyl-7-amide + H2O cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 Fasciola hepatica tert-butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
-
?
tosyl-Ala-Phe-Lys-4-methylcoumarinyl-7-amide + H2O cathepsin L1 Fasciola hepatica tosyl-Ala-Phe-Lys + 7-amino-4-methylcoumarin
-
?
tosyl-Gly-Pro-Arg-4-methylcoumarinyl-7-amide + H2O cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 Fasciola hepatica tosyl-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
?
tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 Fasciola hepatica tosyl-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
?
tosyl-Gly-Pro-Lys-4-methylcoumarinyl-7-amide + H2O cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 Fasciola hepatica tosyl-Gly-Pro-Lys + 7-amino-4-methylcoumarin
-
?
tosyl-Gly-Pro-Lys-7-amido-4-methylcoumarin + H2O cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 Fasciola hepatica tosyl-Gly-Pro-Lys + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
cathepsin L1
-
Fasciola hepatica

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.002
-
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.002
-
benzyloxycarbonyl-Arg-Arg-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.01
-
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.01
-
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.02
-
H-Leu-Val-Tyr-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.02
-
t-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.02
-
tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.02
-
H-Leu-Val-Tyr-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.03
-
tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.03
-
tosyl-Gly-Pro-Lys-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.03
-
benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.03
-
tosyl-Gly-Pro-Arg-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.03
-
benzoyl-Phe-Val-Arg-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.03
-
tosyl-Gly-Pro-Lys-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.04
-
benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.04
-
benzyloxycarbonyl-Arg-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
0.05
-
succinyl-Ala-Phe-Lys-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
0.05
-
succinyl-Ala-Phe-Lys-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
1.08
-
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
1.08
-
benzyloxycarbonyl-Phe-Arg-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica
7.9
-
t-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin pH 7.0, 37°C Fasciola hepatica
7.9
-
tert-butyloxycarbonyl-Val-Leu-Lys-4-methylcoumarinyl-7-amide pH 7.0, 37°C, cathepsin L1 Fasciola hepatica