Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | cathepsin L2 is completely inactivated by 4 mM tetranitromethane, cathepsin L1 is not inactivated | Fasciola hepatica |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0054 | - |
H-Leu-Val-Tyr-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.0054 | - |
H-Leu-Val-Tyr-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.0093 | - |
benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.0093 | - |
benzoyl-Phe-Val-Arg-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.0147 | - |
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.0147 | - |
benzyloxycarbonyl-Phe-Arg-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.0204 | - |
benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.0204 | - |
benzyloxycarbonyl-Arg-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.026 | - |
tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.026 | - |
tosyl-Gly-Pro-Arg-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.0347 | - |
t-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.0347 | - |
tert-butyloxycarbonyl-Val-Leu-Lys-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.0385 | - |
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.0385 | - |
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.0436 | - |
t-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.0436 | - |
tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.0653 | - |
succinyl-Ala-Phe-Lys-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.0653 | - |
succinyl-Ala-Phe-Lys-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.0656 | - |
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.0656 | - |
benzyloxycarbonyl-Arg-Arg-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.1069 | - |
tosyl-Gly-Pro-Lys-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.1069 | - |
tosyl-Gly-Pro-Lys-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Fasciola hepatica | cathepsin L1 and cathepsin L2 proteinases may be the prime mechanism by which the parasite penetrates tissue | ? | - |
? |
Organic Solvent | Comment | Organism |
---|---|---|
Ethanol | no inactivation of cathepsin L1 or cathepsin L2 | Fasciola hepatica |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Fasciola hepatica | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzoyl-Phe-Val-Arg-4-methylcoumarinyl-7-amide + H2O | cathepsin L1 | Fasciola hepatica | benzoyl-Phe-Val-Arg + 7-amino-4-methylcoumarin | - |
? | |
benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin + H2O | - |
Fasciola hepatica | benzoyl-Phe-Val-Arg + 7-amino-4-methylcoumarin | - |
? | |
benzyloxycarbonyl-Arg-4-methylcoumarinyl-7-amide + H2O | cathepsin L1 | Fasciola hepatica | benzyloxycarbonyl-Arg + 7-amino-4-methylcoumarin | - |
? | |
benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin + H2O | - |
Fasciola hepatica | benzyloxycarbonyl-Arg + 7-amino-4-methylcoumarin | - |
? | |
benzyloxycarbonyl-Arg-Arg-4-methylcoumarinyl-7-amide + H2O | cathepsin L1 | Fasciola hepatica | benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin | - |
? | |
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O | - |
Fasciola hepatica | benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin | - |
? | |
benzyloxycarbonyl-Phe-Arg-4-methylcoumarinyl-7-amide + H2O | cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 | Fasciola hepatica | benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O | cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 | Fasciola hepatica | benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
H-Leu-Val-Tyr-4-methylcoumarinyl-7-amide + H2O | cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 | Fasciola hepatica | H-Leu-Val-Tyr + 7-amino-4-methylcoumarin | - |
? | |
H-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O | - |
Fasciola hepatica | H-Leu-Val-Tyr + 7-amino-4-methylcoumarin | - |
? | |
Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O | cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 | Fasciola hepatica | Leu-Val-Tyr + 7-amino-4-methylcoumarin | - |
? | |
additional information | cathepsin L1 and cathepsin L2 proteinases may be the prime mechanism by which the parasite penetrates tissue | Fasciola hepatica | ? | - |
? | |
succinyl-Ala-Phe-Lys-4-methylcoumarinyl-7-amide + H2O | cathepsin L1 | Fasciola hepatica | succinyl-Ala-Phe-Lys + 7-amino-4-methylcoumarin | - |
? | |
succinyl-Ala-Phe-Lys-7-amido-4-methylcoumarin + H2O | - |
Fasciola hepatica | tosyl-Ala-Phe-Lys + 7-amino-4-methylcoumarin | - |
? | |
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarinyl-7-amide + H2O | cathepsin L1 | Fasciola hepatica | succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin | - |
? | |
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O | - |
Fasciola hepatica | succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin | - |
? | |
t-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O | - |
Fasciola hepatica | t-butyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin | - |
? | |
t-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O | cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 | Fasciola hepatica | t-butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin | - |
? | |
tert-butyloxycarbonyl-Val-Leu-Lys-4-methylcoumarinyl-7-amide + H2O | cathepsin L1 | Fasciola hepatica | tert-butyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin | - |
? | |
tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumarinyl-7-amide + H2O | cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 | Fasciola hepatica | tert-butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin | - |
? | |
tosyl-Ala-Phe-Lys-4-methylcoumarinyl-7-amide + H2O | cathepsin L1 | Fasciola hepatica | tosyl-Ala-Phe-Lys + 7-amino-4-methylcoumarin | - |
? | |
tosyl-Gly-Pro-Arg-4-methylcoumarinyl-7-amide + H2O | cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 | Fasciola hepatica | tosyl-Gly-Pro-Arg + 7-amino-4-methylcoumarin | - |
? | |
tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O | cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 | Fasciola hepatica | tosyl-Gly-Pro-Arg + 7-amino-4-methylcoumarin | - |
? | |
tosyl-Gly-Pro-Lys-4-methylcoumarinyl-7-amide + H2O | cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 | Fasciola hepatica | tosyl-Gly-Pro-Lys + 7-amino-4-methylcoumarin | - |
? | |
tosyl-Gly-Pro-Lys-7-amido-4-methylcoumarin + H2O | cleaved by cathepsin L2 with much greater affinity than by cathepsin L1 | Fasciola hepatica | tosyl-Gly-Pro-Lys + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin L1 | - |
Fasciola hepatica |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.002 | - |
benzyloxycarbonyl-Arg-Arg-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.01 | - |
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.01 | - |
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.02 | - |
H-Leu-Val-Tyr-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.02 | - |
t-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.02 | - |
tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.02 | - |
H-Leu-Val-Tyr-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.03 | - |
tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.03 | - |
tosyl-Gly-Pro-Lys-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.03 | - |
benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.03 | - |
tosyl-Gly-Pro-Arg-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.03 | - |
benzoyl-Phe-Val-Arg-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.03 | - |
tosyl-Gly-Pro-Lys-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.04 | - |
benzyloxycarbonyl-Arg-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.04 | - |
benzyloxycarbonyl-Arg-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
0.05 | - |
succinyl-Ala-Phe-Lys-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
0.05 | - |
succinyl-Ala-Phe-Lys-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
1.08 | - |
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
1.08 | - |
benzyloxycarbonyl-Phe-Arg-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica | |
7.9 | - |
t-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin | pH 7.0, 37°C | Fasciola hepatica | |
7.9 | - |
tert-butyloxycarbonyl-Val-Leu-Lys-4-methylcoumarinyl-7-amide | pH 7.0, 37°C, cathepsin L1 | Fasciola hepatica |